Results 181 to 190 of about 101,524 (316)

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen   +11 more
wiley   +1 more source

Ergodic seismic precursors and transfer learning for short term eruption forecasting at data scarce volcanoes. [PDF]

Nat Commun
Ardid A, Dempsey D, Caudron C, Cronin S, Kennedy B, Girona T, Roman D, Miller C, Potter S, Lamb OD, Martanto A, Cubuk-Sabuncu Y, Cabrera L, Ruiz S, Contreras R, Pacheco J, Mora MM, De Angelis S.   +17 more
europepmc   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

4D seismic tomography unveiling velocity increase prior to seismic swarms at the Tatun volcano group of Taiwan. [PDF]

Sci Rep
Pu HC, Lin CH, Lai YC, Shih MH, Li YH.
europepmc   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Source dynamics of Ruapehu's 2022 volcanic unrest: insights from drumbeat seismicity, tremor, and crater lake signals. [PDF]

Bull Volcanol
Bramwell LA, Illsley-Kemp F, Hughes EC, Butcher S, Lamb OD, Behr Y.   +5 more
europepmc   +1 more source

Incremental learning for Volcano monitoring

, 2018
This document studies the creation of a computer program written in Java programming language to classify seismic movements occurred between 2015 and 2016 collected from volcano Puracé in Colombia, with the inclusion in this system of Data Mining application MOA by the University of Waikato.
openaire   +2 more sources

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

A field resource for the glioma cerebrospinal fluid proteome: Impacts of resection and location on biomarker discovery. [PDF]

Neuro Oncol
Riviere-Cazaux C, Graser CJ, Warrington AE, Hoplin MD, Andersen KM, Malik N, Palmer EA, Carlstrom LP, Dasari S, Munoz-Casabella A, Ikram S, Ghadimi K, Himes BT, Jusue-Torres I, Sarkaria JN, Meyer FB, Van Gompel JJ, Kizilbash SH, Sener U, Michor F, Campian JL, Parney IF, Burns TC.   +22 more
europepmc   +1 more source

Artificial Olfactory System Enabled by Ultralow Chemical Sensing Variations of 1D SnO2 Nanoarchitectures

Advanced Science, EarlyView.
This study presents a highly reliable gas sensor platform featuring SnO2 nanonetworks functionalized with Au and Pd nanocatalysts. Enhanced stability and optimized performance enable over 99.5% classification accuracy in deep learning, even under extreme conditions.
Yun‐Haeng Cho, Dong‐Su Kim, Jung Hwan Seo, Jae Han Chung, Zion Park, Ki Chang Kwon, Jae‐Kwon Ko, Tae Won Ha, Jeong‐O Lee, Gyu‐Li Kim, Seong‐Jun Ro, Hyojung Kim, Chil‐Hyoung Lee, Kwangjae Lee, Young‐Seok Shim, Donghwi Cho   +15 more
wiley   +1 more source