Results 251 to 260 of about 70,139 (338)

Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling

Advanced Science, EarlyView.
The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park, Juhyeon Jo, Kun Xu, Sun‐Ah Lee, Seong‐Beom Han, YigJi Lee, Won‐Ki Cho, Bo Li, Soo Hyun Kim, Dong‐Hwee Kim   +9 more
wiley   +1 more source

Integrating multi-omics and machine learning strategies to explore the "gene-protein-metabolite" network in ischemic heart failure with Qi deficiency and blood stasis syndrome. [PDF]

Chin Med
Wei J, Wang A, Yu P, Sun Y, Wu W, Zhang Y, Yu R, Li B, Zhu M.   +8 more
europepmc   +1 more source

Dual‐Targeted Nanovesicles Induced Cancer Stem‐Like Cell Differentiation to Sensitize Hepatocellular Carcinoma Radiotherapy

Advanced Science, EarlyView.
The existence of Pin1 and Notch1 crosstalk is identified and verified in HCC, and the crucial function of this crosstalk in sustaining the aggressive phenotypes of CSCs and radioresistance. A biomimetic nanovesicle is now developed to block the crosstalk between Pin1 and Notch1 for inducing CSCs differentiation and sensitizing HCC radiotherapy ...
Hongmei Cao, Qian Wang, Yanan Niu, Shuxiang Wang, Haixue Jia, Dianyu Wang, Jinjian Liu, Wei Yuan, Lijun Yang, Jianfeng Liu   +9 more
wiley   +1 more source

Pressurized magma storage in radial dike network beneath Etna volcano evidenced with P-wave anisotropic imaging. [PDF]

Commun Earth Environ
Del Piccolo G, VanderBeek BP, Faccenda M, Lo Bue R, Cocina O, Firetto Carlino M, Giampiccolo E, Scarfí L, Rappisi F, Gerya T, Morelli A.   +10 more
europepmc   +1 more source

PFKFB2‐Driven Glycolysis Promotes Dendritic Cell Maturation and Exacerbates Acute Lung Injury

Advanced Science, EarlyView.
Paraquat (PQ) or lipopolysaccharide (LPS) exposure activates the HIF‐1α–PFKFB2 pathway, driving glycolysis in dendritic cells (DCs). This metabolic shift enhances DC maturation and immune activation, exacerbating acute lung injury (ALI). This study demonstrates that PFKFB2‐driven glycolytic reprogramming in DCs plays a critical role in the pathogenesis
Ding Yuan, Fang Yang, Linlin Hou, Yan Zhang, Xin Pang, Yuqi Du, Hongyi Yan, Huanzhou Zhu, Yue Cheng, Yue Wu, Pinpin Jiang, Mengnan Guo, Mengying Zhang, Jinjie Guo, Huihui Hao, Yong Jiang, Yi Li, Yanxia Gao   +17 more
wiley   +1 more source

Scientific response to the 2024-2025 dyke intrusions in the Fentale-Dofen Region, Ethiopia: geophysical monitoring, surface manifestations, and hazard mapping. [PDF]

Bull Volcanol
Lewi E, Biggs J, Ayele A, Wright T, Pagli C, Keir D, Ali Y, Assefa G, Wang H, La Rosa A, Way L, Mengistu F, Loughlin S, Grandin R, Temtime T, Birhanu Y, Freymueller J, Zheng W.   +17 more
europepmc   +1 more source

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source

High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes. [PDF]

Front Endocrinol (Lausanne)
Miles TK, Odle AK, Byrum SD, Lagasse AN, Haney AC, Ortega VG, Herdman AK, MacNicol MC, MacNicol AM, Childs GV.   +9 more
europepmc   +1 more source

Probing the Challenge of P‐Type Semiconductors in Long‐Chain VOC Detection: 3D Micro‐Flower Zinc Cobaltate Heterojunction Sensors

Advanced Science, EarlyView.
Fe@WO3/ZnCo2O4 n‐p heterojunction sensor exhibits excellent room‐temperature sensing toward tetradecane, with a low detection limit of 78.4 ppb and short recovery time. The good performance is attributed to synergistic effects from heterojunctions, heteroatom doping, oxygen vacancies, high‐energy facets, and theoretical validations.
Kewei Liu, Zichen Zheng, Yiwen Zhou, Carla Bittencourt, Marc Debliquy, Chao Zhang   +5 more
wiley   +1 more source

Triggering the 2022 eruption of Mauna Loa. [PDF]

Nat Commun
Lynn KJ, Downs DT, Trusdell FA, Wieser PE, Rangel B, McDade B, Hotovec-Ellis AJ, Bennington N, Anderson KR, Ruth DCS, DeVitre CL, Ellis AP, Nadeau PA, Clor L, Kelly P, Dotray PJ, Chang JC.   +16 more
europepmc   +1 more source