Results 111 to 120 of about 2,589,650 (335)
The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation. [PDF]
, 2019 Allosteric ligands modulate protein activity by altering the energy landscape of conformational space in ligand-protein complexes. Here we investigate how ligand binding to a K+ channel's voltage sensor allosterically modulates opening of its K ...
Angueyra, Juan M +6 more
core +1 more source
Disorder induced superconducting ratchet effect in nanowires
, 2010 A dc voltage drop develops along amorphous indium oxide nanowires that are exposed to an ac bias source. This voltage is anti-symmetric with magnetic field and is characterized by sample specific quasi-periodic magneto-voltage oscillations.
Frydman, Aviad +2 more
core +1 more source
Theoretic Analysis of the Influence of Heart-Dipole Eccentricity on Limb Leads, Wilson Central-Terminal Voltage and the Frontal-Plane Vectorcardiogram [PDF]
, 1953 Ernest Frank
openalex +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
IEEE AccessIn this paper, we develop a defect target detection algorithm based on image processing and feature matching to address background noise in the detection of defects in infrared images of Unmanned Aerial Vehicle (UAVs), as well as to improve real-time ...
Jining Zhao +5 more
doaj +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
DC-DC Boost Converter with Constant Output Voltage for Grid Connected Photovoltaic Application System [PDF]
, 2010 The main purpose of this paper is to introduce an approach to design a DC-DC boost converter with constant output voltage for grid connected photovoltaic application system.
Chan, Pui Weng
core
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
Frontiers in MicrobiologyThe surge in global energy demand mandates a significant expansion of electric power substations. Nevertheless, the ecological consequences of electric power substation operation, particularly concerning the electromagnetic field, on soil microbial ...
Zhi-Xin Xu +7 more
doaj +1 more source