Results 111 to 120 of about 4,141,576 (334)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Isolating switch state detection system based on depth information guidance

Electronic Research Archive
This study addressed the critical role of isolating switches in controlling circuit connections for the stable operation of the substation. Our research introduced an innovative state detection system that utilized depth information guidance, comprising ...
Hui Xu , Xinyang Zhao, Qiyun Yin , Junting Dou, Ruopeng Liu , Wengang Wang   +5 more
doaj   +1 more source

RF amplification property of the MgO-based magnetic tunnel junction using field-induced ferromagnetic resonance

, 2013
The radio-frequency (RF) voltage amplification property of a tunnel magnetoresistance device driven by an RF external-magnetic-field-induced ferromagnetic resonance was studied.
Dixit, D. K., Fukushima, A., Konishi, K., Kubota, H., Miwa, S., Nozaki, T., Suzuki, Y., Tulapurkar, A. A., Yuasa, S.   +8 more
core   +1 more source

Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites [PDF]

, 2018
Yali Wang, Elaine Yang, Marta M. Wells, Vasyl Bondarenko, Kellie A. Woll, Vincenzo Carnevale, Daniele Granata, Michael L. Klein, Roderic G. Eckenhoff, William P. Dailey, Manuel Covarrubias, Pei Tang, Yan Xu   +12 more
openalex   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Enhanced Infrared Defect Detection for UAVs Using Wavelet-Based Image Processing and Channel Attention-Integrated SSD Model

IEEE Access
In this paper, we develop a defect target detection algorithm based on image processing and feature matching to address background noise in the detection of defects in infrared images of Unmanned Aerial Vehicle (UAVs), as well as to improve real-time ...
Jining Zhao, RuiZhi Zhang, Shaogong Chen, Yanbo Duan, Zhiyuan Wang, Qingchen Li   +5 more
doaj   +1 more source

Large oscillating non-local voltage in multi-terminal single wall carbon nanotube devices

, 2007
We report on the observation of a non-local voltage in a ballistic one-dimensional conductor, realized by a single-wall carbon nanotube with four contacts.
C. Schönenberger, G. Gunnarsson, H. X. Tang, J. Trbovic, M. Jullière, M. S. Dresselhaus   +5 more
core   +1 more source

A Compensation Method for Variations in Subthreshold Slope and Threshold Voltage of Thin-Film Transistors for AMOLED Displays [PDF]

, 2019
Nack‐Hyeon Keum, Chong‐Chul Chai, Seong‐Kwan Hong, Oh‐Kyong Kwon   +3 more
openalex   +1 more source

THE CRYSTAL STRUCTURE OF A VOLTAGE-GATED SODIUM CHANNEL

Nature, 2011
Voltage-gated sodium (NaV) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage-dependent activation, ion selectivity and drug block is ...
J. Payandeh, T. Scheuer, Ning Zheng, W. Catterall   +3 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source