Results 91 to 100 of about 105,219 (309)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

EcoBlock: Grid Impacts, Scaling, and Resilience [PDF]

, 2017
Widespread deployment of EcoBlocks has the potential to transform today's electricity system into one that is more resilient, flexible, efficient and sustainable.
Bariya, Mohini, Ostfeld, Aminy, von Meier, Alexandra, Whitmeyer, Michael   +3 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

DC Link Voltage Balancing for Enhanced Performance in Multilevel Inverter-based Distribution Static Synchronous Compensator

Majlesi Journal of Electrical Engineering
This article describes the use of a sliding mode controller (SMC) in conjunction with an integral (PI) controller for a MLI based DSTATCOM to balance dc side voltage, control a cascaded H-bridge inverter, and compensate for power quality issues related ...
Kalagotla Chenchireddy, Mulla Gouse Basha, Vislavath Kumar, Shabbier Ahmed Sydu   +3 more
doaj   +1 more source

Ripple Analysis and Capacitor Voltage Balancing of Five-Level Hybrid Clamped Inverter (5L-HC) for Medium-Voltage Applications

IEEE Access, 2019
The five-level hybrid clamped inverter (5L-HC) is a promising new topology for medium-voltage applications. However, to minimize the capacitors and ensure good performance of the converter, capacitor voltage ripples, as well as voltage balancing control,
Ze Wang, Chao Gao, Canfeng Chen, Jian Xiong, Kai Zhang   +4 more
doaj   +1 more source

Generalized Voltage-based State-Space Modelling of Modular Multilevel Converters with Constant Equilibrium in Steady-State [PDF]

, 2017
This paper demonstrates that the sum and difference of the upper and lower arm voltages are suitable variables for deriving a generalized state-space model of an MMC which settles at a constant equilibrium in steady-state operation, while including the ...
Bergna-Diaz, Gilbert, D'Arco, Salvatore, Freytes, Julian, Guillaud, Xavier, Suul, Jon Are   +4 more
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Active Capacitor Voltage Balancing Strategy for Stacked Flying Capacitor Half‐Bridge Five‐Level LLC Resonant Converter

IET Power Electronics
A multilevel DC–DC converter is a promising solution to save cost and promote the power density of DC solid‐state transformers. Among the multilevel DC–DC topologies, the stacked flying capacitor half‐bridge five‐level LLC resonant converter can ...
Daoxin Tong, Fan Zhang, Xu Yang, Jiajing Li, Yukun Niu, Wenjie Chen   +5 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Research on Fast SOC Balance Control of Modular Battery Energy Storage System

Energies
Early SOC balancing techniques primarily centered on simple hardware circuit designs. Passive balancing circuits utilize resistors to consume energy, aiming to balance the SOC among batteries; however, this approach leads to considerable energy wastage ...
Jianlin Wang, Shenglong Zhou, Jinlu Mao
doaj   +1 more source