Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
A 60 GHz Class-C Wide Tuning-Range Two-Core VCO Utilizing a Gain-Boosting Frequency Doubling Technique and an Adaptive Bias Scheme for Robust Startup. [PDF]
Psycharis ID, Tsourtis V, Kalivas G.
europepmc +1 more source
Advances in Non-Invasive Neuromodulation: Designing Closed-Loop Devices for Respiratory-Controlled Transcutaneous Vagus Nerve Stimulation. [PDF]
de Faria GM +6 more
europepmc +1 more source
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Optimizing Energy/Current Fluctuation of RF-Powered Secure Adiabatic Logic for IoT Devices. [PDF]
Ribeiro BF, Takahashi Y.
europepmc +1 more source
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Wafer-Level Fabrication of Radiofrequency Devices Featuring 2D Materials Integration. [PDF]
Silva V +5 more
europepmc +1 more source
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source
Impedance Coupled Voltage Boosting Circuit for Polyvinylidene Fluoride Based Energy Harvester. [PDF]
Lee K +5 more
europepmc +1 more source
Single-stage input current shaping technique with voltage-doubler rectifier front-end
A single-stage input-current-shaping (S.sup.2 ICS) converter of the present invention integrates a voltage-doubler-rectifier front-end with a DC/DC output stage. Two families of voltage-doubler S.sup.2 ICS converters are disclosed.
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