Results 81 to 90 of about 1,361,325 (295)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Exploring pulse-voltage-triggered optically induced electrohydrodynamic instability for femtolitre droplet generation

open access: yes, 2014
We present a multipoint "virtual dispenser" to draw femtolitre droplets from a dielectric fluidic thin film using pulse-voltage-triggered optically induced electrohydrodynamic instability (PVT-OEHI).
Wang YC(王越超)   +7 more
core  

State Reconstruction from a Limited Number of Synchronized Phasor Measurements: Application to Voltage Instability Detection [PDF]

open access: yes, 2012
This paper deals with the performance of the wide-area monitoring previously proposed by the authors in [1], [2] for early detection of voltage instability, when a limited number of synchronized phasor measurements is available.
T. Van Cutsem   +3 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Post-breakdown conduction instability of ultrathin SiO 2 films observed in ramped-current and ramped-voltage current-voltage measurements

open access: yes, 2002
Ramped-current and ramped-voltage current-voltage (I-V) measurements were carried out to investigate the conduction in ultrathin SiO 2 films after breakdown, and all the I-V characteristics were plotted on a log-log scale to examine the power law ...
Sun, CQ, Chen, TP, Tse, MS, Fung, S
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

Investigating of size-dependent buckling and instability caused by support forces and electrostatic field in porous annular microplates [PDF]

open access: yesمهندسی مکانیک شریف
In this paper, the static behavior, instability and buckling in porous micro plates under electrostatic field are investigated based on the modified couple stress theory and with regard to modeling, determining equations and solution methods.
Mahdi Mojahedi   +2 more
doaj   +1 more source

Dynamic analysis of voltage instability in AC-DC systems

open access: yes, 1996
This paper presents the analysis and study of voltage collapse at any converter bus in A C-DC systems considering the dynamics of DC system. The problem of voltage instability is acute when HVDC links are connected to weak AC systems, the strength ...
Rao, SS   +3 more
core   +1 more source

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