Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Electrical engineering & Electromechanics, 2018 Introduction. The mode of intermittent current for DC motor with three-phase thyristor rectifier appears in the idle intervals of some mechanisms. Active and passive filters reduce the variable component of the rectified voltage.
Y.V. Kovalova
doaj +1 more source
Synthesis of High-Input Impedance Electronically Tunable Voltage-Mode Second-Order Low-Pass, Band-Pass, and High-Pass Filters Based on LT1228 Integrated Circuits. [PDF]
Sensors (Basel), 2022 Chen HP, Chen SJ, Chang CY.
europepmc +1 more source
Experimental performance of a 1-kilowatt arcjet thruster [PDF]
A formerly unused cathode and anode/nozzle assembly from a flight model arcjet was tested with nitrogen, hydrogen, and nitrogen-hydrogen mixture simulating ammonia decomposition products at arc power levels from about 300 to 950 W.
Nakanishi, S.
core +1 more source
Constant-frequency, variable-duty-cycle multivibrator [PDF]
, 1969 Circuit provides a pulse source of constant frequency with a duty cycle that is adjustable by an external input signal.
Johnson, J. E.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Single Commercially Available IC-Based Electronically Controllable Voltage-Mode First-Order Multifunction Filter with Complete Standard Functions and Low Output Impedance. [PDF]
Sensors (Basel), 2021 Jaikla W +7 more
europepmc +1 more source
Voltage-mode multiphase sinusoidal oscillators using CBTAs
2012 35th International Conference on Telecommunications and Signal Processing (TSP), 2012 A voltage-mode multiphase sinusoidal oscillator (MSO) structure using current backward transconductance amplifier (CBTA) is presented. The oscillator can generate n voltage signals (n being even or odd) equally spaced in phase. n+1 CBTAs, n grounded capacitor and a grounded resistor are used for nth-state oscillator.
Sagbas, Mehmet +3 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Effects of the Sn100 kVp Tube Voltage Mode on the Radiation Dose and Image Quality of Dual-Source Computed Tomography Pulmonary Angiography. [PDF]
Int J Gen Med, 2021 Zhang WG +6 more
europepmc +1 more source