Results 51 to 60 of about 33,313 (293)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Asymmetrical Interleaved DC/DC Switching Converters for Photovoltaic and Fuel Cell Applications—Part 1: Circuit Generation, Analysis and Design

Energies, 2012
A novel asymmetrical interleaved dc/dc switching converters family intended for photovoltaic and fuel cell applications is presented in this paper. The main requirements on such applications are small ripples in the generator and load, as well as high ...
Sergio Serna, Roberto Giral, Javier Calvente, Carlos Andres Ramos-Paja, Eliana Arango   +4 more
doaj   +1 more source

Operational transconductance amplifier-based nonlinear function syntheses [PDF]

, 1989
It is shown that the operational transconductance amplifier, as the active element in basic building blocks, can be efficiently used for programmable nonlinear continuous-time function synthesis.
Linares Barranco, Bernabé, Ramírez Angulo, Jaime, Rodríguez Vázquez, Ángel Benito, Sánchez Sinencio, Edgar   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Interleaved step-up soft-switching DC–DC Boost converter without auxiliary switches

Energy Reports, 2022
A voltage gain interleaved soft switched DC–DC Boost converter without auxiliary switch is proposed in this paper. Step-up characteristics are achieved without using any transformer, coupled inductor, voltage multiplier cell, switched inductor/switched ...
M. Rezvanyvardom, A. Mirzaei, M. Shabani, Saad Mekhilef, Muhyaddin Rawa, Addy Wahyudie, Mahrous Ahmed   +6 more
doaj   +1 more source

Electronic divider and multiplier using photocells Patent [PDF]

, 1969
Electronic divider and multiplier for analog electric ...
Del Duca, A.
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

High Voltage Step-Up Boost Converter Based on a Three-Winding-Coupled Inductor With Voltage Multiplier Cell

IEEE Access
The present paper endeavors to make a significant contribution to the field of high-voltage non-isolated dc-dc converters. This is achieved by utilizing a voltage multiplier cell based on the three-winding coupled inductor technique.
Carolina Albuquerque Caldeira, Mario Lucio da Silva Martins, Marcelo Cabral Cavalcanti, Antonio Dutra Dantas de Almeida, Eduardo Augusto Oliveira Barbosa, Leonardo Rodrigues Limongi   +5 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

An extendable soft‐switched high step‐up converter with near zero‐ripple input current suitable for fuel cell‐powered applications

IET Renewable Power Generation, 2022
In this paper, an extendable high step‐up topology is presented for the low input voltage applications, that is, fuel cell (FC) source. The proposed converter eliminates the pulsating input current and reduces the high input current ripple.
Morteza Dezhbord, Milad Babalou, Parham Mohseni, Md. Rabiul Islam, Lida Ebrahimi Vafaei, Seyed Hossein Hosseini   +5 more
doaj   +1 more source