Results 101 to 110 of about 742,983 (304)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Powerplexer [PDF]

open access: yes, 1973
An electrical power distribution system is described for use in providing different dc voltage levels. A circuit is supplied with DC voltage levels and commutates pulses for timed intervals onto a pair of distribution wires.
Woods, J. M.
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Analysis of the booster DC to DC converter with feedback [PDF]

open access: yes, 2014
The field effect power transistors are used in many applications in electromechanical systems. Control of the field effect power transistors requires isolated 5V control signals and isolated 12V DC sources.
Gladyshev, S. P.   +2 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

IGZO TFT Gate Driver Circuit With Improved Output Pulse

open access: yesIEEE Journal of the Electron Devices Society, 2019
We propose a new gate driver circuit with an improved output pulse using depletion mode amorphous indium gallium zinc oxide thin film transistors. The previous reported gate driver circuit of our group has a weak point. It is that the peak voltage of the
Jin-Ho Kim   +4 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Bridgeless Buck-Boost PFC Rectifier with Positive Output Voltage

open access: yesApplied Sciences, 2019
A bridgeless buck-boost power-factor-correction (PFC) rectifier with positive output voltage is proposed herein. This PFC rectifier operates in the discontinuous conduction mode (DCM). Owing to the DCM, a good performance on PF is easily achieved as well
Kuo-Ing Hwu, Yu-Kun Tai, Yu-Ping He
doaj   +1 more source

Isolated, multiple-output voltage dc-to-dc converter [PDF]

open access: yes, 1969
Isolated, multiple output voltage dc-to-dc converter provides power for television transmitter used in space vehicles. The isolation is accomplished by using a single-end switching transformer circuit.

core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy