Results 121 to 130 of about 244,454 (305)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Voltage Rise Mitigation in Medium-Voltage Networks with Long Underground Cables and Low Power Demand

Energies
Medium-voltage (MV) distribution networks that are spread through larger territory and threatened by extreme weather conditions are sometimes formed by very long underground cable lines.
Deni Ćetković, Josip Žutolija, Vitomir Komen   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Experimental results and analysis from the 11 T Nb3Sn DS dipole

, 2014
FNAL and CERN are developing a 5.5-m-long twin-aperture Nb3Sn dipole suitable for installation in the LHC. A 2-m-long single-aperture demonstrator dipole with 60 mm bore, a nominal field of 11 T at the LHC nominal current of 11.85 kA and 20% margin has ...
Auchmann, B., Chlachidze, G., Karppinen, M., Novitski, I., Zlobin, A. V.   +4 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Optimal Adjustment of Reactive Power in Transmission Systems by Variation of Taps in Static Elements Using the Mean-Variance Mapping Optimization Algorithm

Energies
This work focuses on the problem of optimal reactive power adjustment (ORPA) in electric power systems (EPSs) by implementing the Mean-Variance Mapping Algorithm (MVMO) focusing on the control of static devices such as taps in transformers and static ...
Diego Cevallos, Carlos Barrera-Singaña, Hugo Arcos   +2 more
doaj   +1 more source

Planning and impact of distributed generation in SESB existing system [PDF]

, 2014
In the recent years the electrical power networks are undergoing rapid restructuring and developing process worldwide. Advancement in technologies and concern about the environmental impacts have led to increase interconnection of renewable energy based ...
Rasmin, Kasmawati
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Gate Coupling to Nanoscale Electronics

, 2009
The realization of single-molecule electronic devices, in which a nanometer-scale molecule is connected to macroscopic leads, requires the reproducible production of highly ordered nanoscale gaps in which a molecule of interest is electrostatically ...
A. T. Charlie Johnson, C. M. Lieber, Douglas R. Strachan, E. L. Wolf, J. D. Jackson, J. H. Stathis, M. Ohring, S. M. Sze, Sujit S. Datta   +8 more
core   +2 more sources