Results 61 to 70 of about 258,257 (262)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Optimization of CCGT Start-Up Ramp Rate to Improve Voltage Quality in a 110/220 kV Power System Node

Energies
With the active modernization of power facilities and the increasing deployment of maneuverable combined-cycle gas turbines (CCGTs), the selection of rational start-up strategies becomes increasingly important from the perspective of power quality ...
Madina Maratovna Umysheva, Yerlan Aliaskarovich Sarsenbayev, Dias Raybekovich Umyshev   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

APPLICATION OF HIGH VOLTAGE DIVIDERS FOR POWER QUALITY INDICES MEASUREMENT

Electrical engineering & Electromechanics, 2017
Introduction. Determination of power quality indices in high-voltage power grids allows to find the reasons for the deterioration of the power quality. The relevant national and International Standards for power quality contain relevant norms of quality ...
Y. L. Anokhin, V. O. Brzhezitsky, Ya. O. Haran, I. M. Masliuchenko, O. P. Protsenko, Ye. O. Trotsenko   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Steady-State Analysis of Voltage Deviations and Three-Phase Imbalance in Distribution Networks Considering Spatiotemporal Coupling of Source-Load Uncertainties

Energies
To address the deep spatiotemporal coupling of source-load dual uncertainties attributed to the high penetration of distributed photovoltaics (PVs) and electric vehicles (EVs) into distribution grids, and the difficulty of analyzing composite ...
Shifeng Zhang, Xiao Chang, Min Zhang, Le Gao   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Droop-Based PI-QPR Control Strategy for Islanded Parallel-Inverter Microgrids

Applied Sciences
Parallel-inverter microgrids are prone to PCC voltage distortion during islanded operation with nonlinear and unbalanced loads. Virtual-impedance methods can reshape inverter output impedance, but they also add control complexity and may introduce extra ...
Jinhao Shen, Hua Zhang, Xueneng Su, Yiwen Gao, Kun Zheng, Cheng Long, Xinbo Liu   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source