Results 61 to 70 of about 49,417 (262)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Voltage Control Approach With Dynamic Voltage Reference for PV Distributed Generation Operating Under Cloud-Induced Shading Conditions

IEEE Access
The integration of photovoltaic generation into distribution systems can deteriorate the system voltage and the conventional voltage regulation process based on step voltage regulators. The system operation under cloud conditions is much more challenging
Glorio Arnaldo Landbrug, Geremi Gilson Dranka, Ricardo Vasques de Oliveira   +2 more
doaj   +1 more source

A 21-Gb/s Dual-Channel Voltage-Mode Transmitter With Stacked NRZ and PAM4 Drivers

IEEE Access, 2018
This paper describes a voltage-mode transmitter that stacks independent non-return-tozero (NRZ) and four-level pulse amplitude modulation (PAM4) drivers for dual channels.
Sung-Ha Kim, Sang-Hoon Kim, Xuefan Jin, Yoonmyung Lee, Jung-Hoon Chun   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Introducing The Radiation-Hardened Voltage Regulators Rhfl4913 and the Rhfl6000

E3S Web of Conferences, 2017
With the progressive scaling of the modern CMOS processes arising during the recent years, for the devices operating in space the susceptivity to the over-voltage events has increased. They have become more stringent the requirements in terms of accuracy
Bonna G., Ribellino C., Pappalardo S.
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Enhancing power distribution performance through simultaneous optimization of voltage regulators placement and conductor selection: A multi-period MILP approach

Results in Engineering
Maintaining optimal voltage profiles and minimizing technical losses are critical challenges in power distribution systems, particularly under significant load fluctuations.
Luis A. Gallego Pareja, Jesús M. López-Lezama, Oscar Gómez Carmona   +2 more
doaj   +1 more source

Application of the theory of bifurcations to the analysis of the stability of impulse voltage stabilizers of a rising type

Физика волновых процессов и радиотехнические системы, 2019
This article discusses the application of the theory of bifurcation to pulsed voltage up-stabilizers, studied its behavior, and analyzed the stability conditions for varying various parameters of the system.
A.A. Voronoi, R.M. Zakirov, D.V. Mishin
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source