Results 181 to 190 of about 3,108 (255)

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

Neuronal plasticity at puberty in mouse hypothalamic <i>Kiss1</i> neurons that control fertility. [PDF]

Proc Natl Acad Sci U S A
Zhang Y, Pakulat LM, Takács S, Campbell L, Galliano E, Hrabovszky E, Colledge WH, Jones S.   +7 more
europepmc   +1 more source

1177. Streptocarpus aylae T.J.Edwards

Curtis's Botanical Magazine, EarlyView.
Summary Streptocarpus aylae T.J.Edwards, a spectacular, rosette forming herbaceous perennial from cliffs of the Msikaba River in Pondoland, Eastern Cape Province, South Africa is illustrated and discussed. The species is known from only two sites and is highly localised, growing in humus rich cracks and crevices on sandstone cliffs.
Paul Rees, Adam Harrower, Ernst J. Van Jaarsveld, Thomas E.M. Pickering, Carel J. Fourie, Dirk U. Bellstedt, Christabel King   +6 more
wiley   +1 more source

A comprehensive review of HCN channel expression and I_h in the auditory system: then, now, and future perspectives. [PDF]

J Neurophysiol
Ordiway G, McLellan K, Sanchez JT.
europepmc   +1 more source

Extreme weather and economic crisis in the 1430s in England, and the implications for tenurial change

The Economic History Review, EarlyView.
Abstract The 1430s were characterized by extreme weather conditions, food and fodder shortages, and high mortalities among animals and humans, although the severity of events and their consequences in England have received limited attention. The economic downturn and the depressed customary land market in this decade marked the beginning of the Great ...
Mark Bailey
wiley   +1 more source

Robust Federated-Learning-Based Classifier for Smart Grid Power Quality Disturbances. [PDF]

Sensors (Basel)
Alsabaan M, Elsayed A, Bondok A, Badr MM, Mahmoud M, Alshawi T, Ibrahem MI.   +6 more
europepmc   +1 more source

Computed tomographic diagnosis and treatment of pneumolabyrinth in a mare with temporohyoid osteoarthropathy

Equine Veterinary Education, EarlyView.
Summary Pneumolabyrinth, which is the presence of gas within the labyrinth of the inner ear, can be associated with severe peripheral vestibular signs. This report describes a case of pneumolabyrinth in a horse that presented with vestibular ataxia. An 8‐year‐old Quarter Horse mare that presented with cranial nerve VII deficits underwent a standing ...
C. A. Jamieson, J. Jarvis, O. Nagasaka, M. Murakami, C. V. Fulkerson, A. C. B. C. F. Pinto   +5 more
wiley   +1 more source

Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease. [PDF]

Epilepsia
Costa C, Bellingacci L, Canonichesi J, Imperatore V, Taddei AA, Zafra-Puerta L, Iglesias-Cabeza N, Prontera P, Mancini A, Di Filippo M, Tozzi A, Martinello K, Barzasi M, Gardoni F, Sánchez MP, Serratosa JM, Parnetti L, Sciaccaluga M.   +17 more
europepmc   +1 more source

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

The FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List, Eva‐Maria Jülke, Annette G. Beck‐Sickinger   +2 more
wiley   +1 more source

Cell Type-Specific Alterations in Excitability and Inhibition of Upper Motor Neurons in AlsinKO Mice, a Model of Juvenile Onset ALS. [PDF]

J Neurosci
Dey S, Quintanilla C, Bitlis D, Gautam M, Ozdinler PH, Martina M.   +5 more
europepmc   +1 more source