Results 61 to 70 of about 4,210,114 (293)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Analysis and design of SOI MEMS step up voltage converters
, 2013 Energy harvesting systems are becoming an increasingly popular area for research as they present themselves as a clean, renewable source of energy. There are currently some key design issues facing the development of these energy harvesting systems.
Gleeson, Rachel
core +1 more source
Família de retificadores PWM unidirecionais três-níveis híbridos a capacitor chaveado com elevado fator de potência [PDF]
, 2015 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Elétrica, Florianópolis, 2015.Esta tese de doutorado tem por objetivo a proposta de uma nova família de conversores ca-cc três níveis ...
Cortez, Daniel Flores
core
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Inversor multiníveis híbrido trifásico baseado em módulos meia-ponte [PDF]
, 2011 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia ElétricaO presente trabalho aborda o desenvolvimento e a implementação de novas estruturas de conversores multiníveis para inversores ...
Batschauer, Alessandro Luiz
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Repetitive current control of two-level and interleaved three-phase PWM utility connected converters
, 2012 This thesis is mainly concerned with investigations into digital repetitive current controlof two-level and interleaved utility connected PWM converters.
Jamil, Mohsin
core +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Loss comparison of 2 and 3-level inverter topologies
, 2010 This paper investigates semiconductor and DC-link capacitor losses in two two-level and two three-level voltage source inverters. The components of the four inverters are selected to have appropriate voltage and current ratings.
Orfanoudakis, G. +3 more
core +1 more source