Results 61 to 70 of about 75,195 (358)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Circuit for clamping bridge overvoltages in voltage-fed quasi-Z-source converter [PDF]

open access: yes, 2016
Unlike the voltage source converter, the Z-source converter can boost as well as buck the input voltage. However, the presence of physically large components in the impedance network introduces large parasitic inductances into power device commutation ...
Kitson, Joanne, McNeill, J N
core   +2 more sources

A Modified Single-Phase Transformerless Y-Source PV Grid-Connected Inverter

open access: yesIEEE Access, 2018
V-source inverter can obtain a high output voltage by using a small shoot-through duty ratio and especially applies to the occasions of large range input voltage, such as photovoltaic (PV) power generation, and so on.
Hongpeng Liu   +4 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Power Quality Improvement Wind Energy System Using Cascaded Multilevel Inverter [PDF]

open access: yes, 2013
In this paper, a wind energy conversion system based on a cascaded H-bridge multilevel inverter (CHBMLI) topology has been proposed to be used for the grid interface of large split winding alternators (SWAs).
A. S., Kumar, J.S., Sathiyanarayanan
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

A multi-level converter with a floating bridge for open-ended winding motor drive applications [PDF]

open access: yes, 2016
This paper presents a dual three phase open end winding induction motor drive. The drive consists of a three phase induction machine with open stator phase windings and dual bridge inverter supplied from a single DC voltage source. To achieve multi-level
Chowdhury, Shajjad   +3 more
core   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

open access: yesFEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah   +8 more
wiley   +1 more source

A PWM current source-based DC transmission system for multiple wind turbine interfacing [PDF]

open access: yes, 2014
A pulsewidth modulation (PWM) current source wind energy conversion system based on a parallel configuration for high voltage direct current application is proposed.
Ahmed, Khaled Hani   +2 more
core   +1 more source

Series-type switched-inductor Z-source inverter

open access: yesCES Transactions on Electrical Machines and Systems, 2020
To solve the disadvantages of the traditional Z-source inverter (ZSI), this paper investigates a series-type switched-inductor Z-source inverter (SSI-ZSI) topology.
Xupeng Fang   +3 more
doaj   +1 more source

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