Results 91 to 100 of about 769,031 (295)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Perkiraan Kestabilan Tegangan Secara Dinamis Menggunakan Eksponen Lyapunov Maksimum

Jurnal Nasional Teknik Elektro, 2015
Disturbances in the operation of the power system may cause disturbance in voltage stability. Therefore, dynamic voltage stability analysis before and after disturbance needs to be performed. This paper proposes dynamic voltage stability prediction using
M. Widi Triyatno, Osea Zebua, I Made Ginarsa   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Power System Voltage Stability Analysis [PDF]

, 2011
Power system is facing new challenges as the present system is subjected to severely stressed conditions. Voltage instability is a quite frequent phenomenon under such a situation rendering degradation of power system performance.
Reddy, C M
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Short-term voltage stability analysis in power systems: A voltage solvability indicator

International Journal of Electrical Power & Energy Systems
This paper presents an analytical study for short-term voltage stability based on a novel indicator. First, it is shown that the reduced Jacobian matrix of network equations can be transformed to obtain an approximately symmetric matrix which is usually ...
Wenqing Hao, Xueyi Wang, Yifan Yao, Deqiang Gan, Minquan Chen   +4 more
doaj   +1 more source

Some studies on the deformation of the membrane in an RF MEMS switch [PDF]

, 2008
Radio Frequency (RF) switches of Micro Electro Mechanical Systems (MEMS) are appealing to the mobile industry because of their energy efficiency and ability to accommodate more frequency bands.
Ambati, V.R., Asheim, A., Berg, van den, J.B., Bokhove, O., et al., xx, Gennip, van, Y., Gerasimov, T., Hlod, A.V., Planqué, R., Schans, van der, M., Stelt, van der, S., Vargas Rivera, M., Vondenhoff, E.   +12 more
core   +1 more source