Results 61 to 70 of about 3,608 (215)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A Switched-Coupled-Inductor Quasi-Z-Source Network With High Boost Capability

IEEE Access
This paper proposes a new high gain quasi-Z-source network (qZSN) using a two-winding switched-coupled-inductor (SCL). By employing a two-winding SCL within the impedance network, the proposed topology offers high boost capability at low shoot-through ...
Mehran Moslehi Bajestan, Hamed Bizhani
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Multi-Input DC-DC Converter for Nanogrid Integration with Solar Photovoltaic Systems [PDF]

Journal of Renewable Energy and Environment
Nowadays, multi-input DC-DC converters are increasingly prevalent in the field of renewable energy sources to address their fluctuating nature. This research article presents a high-power density dual-source DC-DC converter with reduced switch voltage ...
Sivaram Natarajan Vijayanathan, Irfan Ahmad Khan, Lavanya Anbazhagan, Pradeep Vishnuram, Mohit Bajaj   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Novel High Step-Up DC-DC Converter Based on KY Converter [PDF]

Journal of Electrical and Electronics Engineering, 2017
High voltage gain dc-dc converters are widely using in solar systems, fuel cell and automobile electronic lamp ballast. The voltage gain of the classic converters is limited considering the issues such as the high voltage stress on the switch and diode ...
AJDARFAEGHI BONAB Hossein, BANAEI Mohamad Reza   +1 more
doaj  

Solution to reduce voltage stress of sub-module in LCC–MMC transmission system at the condition of communication fault

The Journal of Engineering, 2018
Line commutate converter–modular multilevel converter (LCC–MMC) hybrid high voltage direct current (HVDC) system combines the advantages of both LCC-HVDC and MMC-HVDC, and will be wildly used in the future.
Dengjiang Xing, Jianjun Su, Dingwen Hu, Shumin Sun, Yan Chen, Xianwei Wang, Jun Zhang, Weizheng Yao, Jinlong Wu   +8 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source