Results 61 to 70 of about 1,578,109 (354)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Incremental learning for large-scale stream data and its application to cybersecurity [PDF]
, 2015 As many human currently depend on technologies to assist with daily tasks, there are more and more applications which have been developed to be fit in one small gadget such as smart phone and tablet.
Ali, Siti Hajar Aminah
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Enhanced DVR Control System Based on the Harris Hawks Optimization Algorithm
IEEE Access, 2020 The dynamic voltage restorer's (DVR) transient, steady-state, and dynamic responses are essential requirements for protecting sensitive loads against upstream voltage disturbances via the DVR's ride-through capabilities.
Zeinab Elkady +3 more
doaj +1 more source
Single-phase series active conditioner for the compensation of voltage harmonics, sags, swell and flicker [PDF]
, 2011 Simulation and experimental results shown on this paper describes the performance of a developed Single-Phase Series Active Conditioner that regulates the voltage being delivered to a load.
Afonso, João L. +2 more
core +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Data, 2022 This paper proposes an easy-to-implement method for detecting and assessing two of the most frequent PQ (Power Quality) problems: voltage sags and swells. These can affect sensitive equipment such as computers, programmable logic controllers, contactors,
Javier Fernández-Morales +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
e-Prime: Advances in Electrical Engineering, Electronics and EnergyNowadays, power quality issues; specifically, voltage sag, swell, harmonics, and interruptions have become significant challenges for customers in Ethiopia.
Beliyou Molla +3 more
doaj +1 more source