Results 71 to 80 of about 119,844 (307)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Transformer regulated self-stabilizing chopper [PDF]

open access: yes, 1969
A self-stabilizing voltage regulator is described. Direct current voltage regulation employing a series transistor rendered conductive during various portions of a cycle is controlled by saturation of an autotransformer. The constant volt-second capacity
Raposa, F. L.
core   +1 more source

Active Electrically Small Antenna Based on Superconducting Quantum Array

open access: yes, 2012
We introduce Superconductive Quantum Arrays (SQAs) and propose to use these structures as active Electrically Small Antennas (ESA). Several prototypes of the active ESA were fabricated using Nb process with critical current density 4.5 kA/cm2 and ...
Klenov, Nikolay V.   +4 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Analysis of influence factors of polarization spectrum method on state detection of transformer oil-paper insulatio

open access: yesGong-kuang zidonghua, 2014
Application principle of polarization spectrum method based on recovery voltage method was introduced which was used in state detection of transformer oil-paper insulation, and a viewpoint was pointed out that main time constant of polarization spectrum ...
TAO Fengyuan   +3 more
doaj   +1 more source

The measurement of very low conductivity and dielectric loss in XLPE cables: A possible method to detect degradation due to thermal aging [PDF]

open access: yes, 2011
The dielectric response of crosslinked polyethylene (XLPE) insulated, miniature power cables, extruded with inner and outer semicons, was measured over the frequency range 10-4 to 104 Hz at temperatures from 20 to 100 °C.
Dissado, L. A.   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of shield placement for transient voltage mitigation due to switching surges in a 33/11 kV transformer windings.

open access: yesPLoS ONE, 2020
This study presents an investigation on the effect of shield placement for mitigation of transient voltage in a 33/11 kV, 30 MVA transformer due to Standard Switching Impulse (SSI) and Oscillating Switching Impulse (OSI) surges.
Avinash Srikanta Murthy   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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