Results 81 to 90 of about 69,905 (289)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Degradation Assessment of In-Service Transformer Oil Based on Electrical and Chemical Properties

Applied Sciences
In order to ensure the long-term reliability and safety of power transformers, it is important to continuously monitor the characteristics of insulating oil, which not only helps in understanding its behavior over time but also ensures the safety of the ...
Ehtasham Mustafa, Bilal Ahmad, Malik Imran Ali, Ramy S. A. Afia, Rahmat Ullah   +4 more
doaj   +1 more source

Paper making from bagasse [PDF]

, 2020
Though the revolution of technology has reduced paper production everywhere around the world, the amount of paper consumed each day is still tremendously large.
Abu Bakar Sidik, Dilaeleyana, Mohd Adnan, Raudah, Mohd Aripen, Nur Shahirah, Mohd Ghazali, Jamilah, Mohd Ismail, Nurul Izzati, Rahmat, Ainol Atira, Rosli, Nur Farah Aina, Zahari, Nur Afiqa Zuriati   +7 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Modeling of traction power supply systems for movement of high-speed trains

MATEC Web of Conferences, 2018
Upgrading of traction power supply systems will be required to transfer electrified railway lines to high-speed traffic. Coaxial cables and balancing transformers can be used as technical upgrading means.
Cherepanov Aleksandr, Zakaryukin Vasily, Kryukov Andrey   +2 more
doaj   +1 more source

Ground Fault Protection Using Open Break Delta Grounding Transformer in Ungrounded System

Logic, 2019
One of the most common and difficult problems to solve in distribution power systems is the location and elimination of the ground fault. For the study of an electrical distribution network in ungrounded system operating at 20 kV on the primary and 380 V
Supriyanto Suhono, Hari Purnama, Heri Budi Utomo   +2 more
doaj   +1 more source