Results 41 to 50 of about 79,309 (294)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Electromagnetic field calculation for 110 kV power line [PDF]

Problems of the Regional Energetics, 2015
The paper studies the evolution of values for the characteristic electric field and magnetic field generated by power line voltages and currents voltage 110 kV their value based snapshots.
Berzan V., Patsyuk V., Ribacova G, Ermuratschii V.   +3 more
doaj  

Modelling and Control of a Three-Level Diode-Clamped Medium Voltage Distribution Static Synchronous Compensator using Space Vector Pulse Width Modulation

Gazi University Journal of Science, 2020
Efficient utilization of power networks under extreme voltage sags and swells and reducing the losses are widely recognized as the most important issues in energy industry. Power electronic converter based flexible AC transmission system (FACTS) devices play a significant role in power flow control, power quality improvement, voltage regulation and ...
Fatih EROĞLU, Husnain Ul Haseeb KAZMI, Ahmet Mete VURAL   +2 more
openaire   +3 more sources

Status of insecticide susceptibility in Anopheles gambiae s.l. from malaria surveillance sites in The Gambia. [PDF]

, 2009
BACKGROUND: Vector control is an effective way of reducing malaria transmission. The main vector control methods include the use of insecticide-treated bed nets and indoor residual spraying (IRS).
Betson, M, Betson, Martha, Awolola, Taiwo Samson, Awolola, T S, Natural History Museum, Jawara, Musa, LSHTM, Jawara, M, Malaria Research Programme, Gambia, Nigerian Institute of Medical Research, Martha Betson, Taiwo Samson Awolola, Musa Jawara   +12 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Vector Form Implementation in Three-Phase Power Flow Analysis Based on Power Injection Rectangular Coordinate

Jurnal Nasional Teknik Elektro, 2019
This paper aims to propose the vector form implementation into three-phase power flow analysis. The developed algorithm is based on Newton-Raphson method with voltage is represented in rectangular coordinate.
Lukmanul Hakim, Fandi Prayoga, Khairudin Khairudin, Herri Gusmedi   +3 more
doaj   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source