Results 81 to 90 of about 16,902,208 (330)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Interactive volume illumination of slice-based ray casting [PDF]
, 2020 Dening Luo
openalex +1 more source
PERcursos Linguísticos, 2021 v. 11 n. 29 (2021): Revista PERcursos Linguísticos - Dossiê temático • O texto na pesquisa e no ensino: conhecimentos, práticas e desafios na ...
openaire +3 more sources
A LONGITUDINAL ANALYSIS REGARDING THE EVOLUTION OF PROFIT TAX REGULATIONS IN ROMANIA - AN EMPIRICAL VIEW [PDF]
The study conducted a longitudinal analysis regarding Romanian profit tax regulations. Beginning with the first profit tax regulation implemented in 1991 and until now, we analyzed based on a empirical approach all changes that have occurred over time in
Albu Catalin Nicolae +3 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
E-GOVERNMENT: A DRIVING FACTOR FOR STIMULATING INNOVATION PERFORMANCE IN ROMANIA? [PDF]
The development of public services is one of the priorities on the agendas of all policies, both national and European. One of the most recent concerns of the European Commission, as shown in the 2010 Innobarometer, is to find ways and develop strategies
Coculescu Cristina +3 more
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Trends in Computational and Applied Mathematics, 2010 De acordo com os critérios adotados, estão habilitados a submeter artigos parapublicação em uma Seleta de CNMAC aqueles autores que apresentaram os correspondentes trabalhos no evento.
Volume 11(1) - TEMA
doaj +2 more sources