Results 101 to 110 of about 8,018,700 (214)

GRADUAÇÃO EM GERONTOLOGIA NA PUC-SP: O DESAFIO DA LONGEVIDADE

, 2010
A questão da longevidade tem-se imposto na pós-modernidade não só porque se vive mais como também se vive mais tempo na velhice. A Gerontologia é um campo que transforma tal constatação numa proposição problemática, investigando o impacto social e ...
Suzana Carielo Fonseca, Elisabeth Frohlich Mercadante, Flamínia M. M. Lodovici   +2 more
core  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Brazilian Guidelines for Cardiac Implantable Electronic Devices - 2023. [PDF]

Arq Bras Cardiol, 2023
Teixeira RA, Fagundes AA, Baggio Junior JM, Oliveira JC, Medeiros PTJ, Valdigem BP, Teno LAC, Silva RT, Melo CS, Elias Neto J, Moraes Júnior AV, Pedrosa AAA, Porto FM, Brito Júnior HL, Souza TGSE, Mateos JCP, Moraes LGB, Forno ARJD, D'Avila ALB, Cavaco DAM, Kuniyoshi RR, Pimentel M, Camanho LEM, Saad EB, Zimerman LI, Oliveira EB, Scanavacca MI, Martinelli Filho M, Lima CEB, Lima CEB, Peixoto GL, Darrieux FCDC, Duarte JOP, Galvão Filho SDS, Costa ERB, Mateo EIP, Melo SL, Rodrigues TDR, Rocha EA, Hachul DT, Lorga Filho AM, Nishioka SAD, Gadelha EB, Costa R, Andrade VS, Torres GG, Oliveira Neto NR, Lucchese FA, Murad H, Wanderley Neto J, Brofman PRS, Almeida RMS, Leal JCF.   +52 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Serum Levels of BDNF in Cardiovascular Protection and in Response to Exercise. [PDF]

Arq Bras Cardiol, 2020
Trombetta IC, DeMoura JR, Alves CR, Carbonari-Brito R, Cepeda FX, Lemos JR.   +5 more
europepmc   +1 more source

Estudo da longevidade de vacas zebu?nas

, 2016
Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2017-09-28T00:08:27Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) diana_carla_fernandes_oliveira.pdf: 1785085 bytes, checksum ...
Oliveira, Diana Carla Fernandes
core  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Gramado consensus on imaging evaluation of the response to neoadjuvant systemic therapy for breast cancer. [PDF]

Radiol Bras
Urban LABD, Chala LF, de Paula IB, Miranda BMM, Bitencourt AGV, Moraes PC, Mussauer ACMR, Benetti CCTP, Racy ACS, Carli L, Thompson BM, Couto HL, Pessoa EC, Freitas NMA, Argolo DFSTE, Carvalho FM.   +15 more
europepmc   +1 more source