Results 51 to 60 of about 8,018,700 (214)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Instrumentos financeiros para Hedge de longevidade [PDF]
, 2017 Analisa as possibilidades de proteção contra os riscos atrelados à longevidade praticados atualmente no mundo. O crescente aumento da expectativa de vida preocupa aqueles que são responsáveis por sua respectiva mensuração.
Dantas, Isabela, Petra Bisneto, Paulo
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
A longevidade nas notas de falecimento
, 2010 O processo do aumento da longevidade no Brasil pode ser evidenciado pelas notas de falecimento de idosos. A longevidade é um fenômeno atual no país e é determinada pelo tempo de vida maior alcançado pelos idosos.
Rodrigo Caetano Arantes, Beltrina Côrte
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Longevidade: Cidadania, Participação e Direitos Sociais
, 2017 A longevidade é sem dúvida uma das maiores conquistas da humanidade. O aumento do número de pessoas nos grupos etários mais elevados (+65) é essencialmente, fruto de um conjunto de políticas públicas e sociais, que nas últimas décadas foram implementadas
Isabel Maria Gomes De Oliveira +1 more
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Gestão por Processo e Inovação para Aprimorar Governança Municipal da Longevidade
, 2020 Relato da experiência de capacitação para gestores públicos municipais no diagnóstico de preparação das cidades para longevidade e na metodologia de gestão por processos e inovação para aprimorar a governança municipal da ...
Cristiane Chaves Gattaz
core +1 more source