Results 71 to 80 of about 20,430,785 (263)

Dagstuhl Reports, Volume 6, Issue 1, January 2016, Complete Issue

, 2016
Dagstuhl Reports, Volume 6, Issue 1, January 2016, Complete ...

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MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Dagstuhl Reports, Volume 6, Issue 8, August 2016, Complete Issue

, 2017
Dagstuhl Reports, Volume 6, Issue 8, August 2016, Complete ...

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Volume 6 Credits [PDF]

Credits, Volume 6
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A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Dagstuhl Reports, Volume 6, Issue 9, September 2016, Complete Issue

, 2017
Dagstuhl Reports, Volume 6, Issue 9, September 2016, Complete ...

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Cover Depan

Jentera: Jurnal Kajian Sastra, 2017
Jentera, Volume 6, Nomor1
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Division 6 Biweekly Report, July 3, 1953

, 1953
Bi-weekly progress report of Division 6 research ...
Division 6 Research Staff
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Dagstuhl Reports, Volume 4, Issue 6, June 2014, Complete Issue

, 2015
Dagstuhl Reports, Volume 4, Issue 6, June 2014, Complete ...

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