Results 91 to 100 of about 4,020,070 (373)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A biophysical-based skin model for heterogeneous volume rendering

Computational Visual Media
Realistic human skin rendering has been a long-standing challenge in computer graphics. Recently, biophysical-based skin rendering has received increasing attention, as it provides a more realistic skin-rendering and a more intuitive way to adjust the ...
Qi Wang, Fujun Luan, Yuxin Dai, Yuchi Huo, Hujun Bao, Rui Wang   +5 more
doaj   +1 more source

Photo-realistic image synthesis in volume rendering for rapid prototyping and CAM applications (draft) [PDF]

, 2002
This document describes some preliminary results of the application of direct volume visualization and realistic image synthesis techniques in Computer Aided Manufacturing (CAM) field.
Pili, Piero, Scalas, Alceste
core  

Differentiable Rendering with Reparameterized Volume Sampling [PDF]

, 2023
Н. Ф. Морозов, Denis Rakitin, Oleg Desheulin, Dmitry Vetrov, Kirill Struminsky   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Implementation of a WebGPU-Based Volume Rendering Framework for Interactive Visualization of Ocean Scalar Data

Applied Sciences
Visualization contributes to an in-depth understanding of ocean variables and phenomena, and a web-based three-dimensional visualization of ocean data has gained significant attention in oceanographic research.
Jiaqi Yu, Rufu Qin, Zhounan Xu
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Enhancing View Synthesis with Depth-Guided Neural Radiance Fields and Improved Depth Completion

Sensors
Neural radiance fields (NeRFs) leverage a neural representation to encode scenes, obtaining photorealistic rendering of novel views. However, NeRF has notable limitations.
Bojun Wang, Danhong Zhang, Yixin Su, Huajun Zhang   +3 more
doaj   +1 more source

Acceleration Approach for Neural Radiance Field in Dynamic 3D Human Reconstruction [PDF]

Jisuanji gongcheng
This study proposes a novel acceleration method for the Neural Radiance Field (NeRF) in dynamic 3D human reconstruction to address the challenges of low training efficiency and high computational complexity in volume rendering.
XIAO Yilong, DENG Yiqin, CHEN Zhigang
doaj   +1 more source