Results 111 to 120 of about 33,794 (304)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Resistivity of Ca-Al metallic glasses [PDF]

, 1986
The resistivity of Ca-Al metallic glass is calculated as a function of temperature and composition. The diffraction model is used, including the partial dynamic structure factors.
Laakkonen, J., Nieminen, Risto M., Nieminen, R. M.   +2 more
core   +1 more source

Self-sensing performance and electrode configuration analysis of carbon black-modified UHPCC

Shenzhen Daxue xuebao. Ligong ban
To achieve the self-sensing performance of ultra-high performance cementitious composites (UHPCC), modified UHPCC specimens were prepared with carbon black as a conductive filler.
LIN Weidong, SHI Ke, ZHANG Yafang, BAO Sihai, DUAN Libin, XU Jingbin   +5 more
doaj   +1 more source

Thyroid Volume and Doppler Indices of the Inferior Thyroid Artery in Clinically Euthyroid Adults in Kashmir

Galician Medical Journal, 2018
The objective of the research was to evaluate thyroid volume and spectral indices (the resistivity index, the pulsatility index and the peak systolic velocity) in normal euthyroid adults in Kashmir.          Materials and methods.
Imran Nazir Salroo, Nasir Ahmad Lone, Musharaf Bashir   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Effects of Resistance Training Volume on Skeletal Muscle Proteome

International Journal of Exercise Science, 2017
Studies are conflicting to whether low volume resistance training (RT) is as effective as high-volume RT protocols with respect to promoting morphological and molecular adaptations. Thus, the aim of the present study was to compare, using a climbing a vertical ladder, the effects of 8 weeks, 3 times per week, resistance training with 4 sets (RT4 ...
Ramires A. Tibana, Octávio L. Franco, Gabriel V. Cunha, Nuno M. F Sousa, Ivo V. Sousa Neto, Márcia M. Carvalho, Jeeser Alves de Almeida, James W. Navalta, Mariana O. Lobo, Fabricio A. Voltarelli, Rita C. Marqueti, João L.Q. Durigan, Jonato Prestes   +12 more
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The effective area of measurement electrode in volume resistivity and permittivity of solid dielectrics measurements [PDF]

, 2015
The problems of determination of the effective area of the measurement electrode during the evaluation of volume resistivity and electrical permittivity based on measurements in three electrode system are discussed.
Lisowski, M., Kołakowska, D.
core  

Genesis of Low-Resistivity Shale Reservoirs and Its Influence on Gas-Bearing Property: A Case Study of the Longmaxi Formation in Southern Sichuan Basin

Applied Sciences
To mitigate the exploration and development risks, it is necessary to have a deeper understanding of the formation mechanism and gas-bearing control factors of low-resistance shale reservoirs.
Xi Hu, Anfu Zhou, Yading Li, Hongzong Jiang, Yonghong Fu, Yuqiang Jiang, Yifan Gu   +6 more
doaj   +1 more source