Results 231 to 240 of about 2,687,345 (274)

Prevalence and socio-demographic factors associated with transfusion transmissible infections among voluntary blood donors in Kigali, Rwanda. [PDF]

BMC Infect Dis
Uwumuryango P, Sebera E, Gashaija C, Gasana J, Andegiorgish AK.   +4 more
europepmc   +1 more source

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Blood donor deferral patterns in Iran: six-year national analysis (2016-2021). [PDF]

Blood Transfus
Kasraian L, Sadeghi E, Khakrah Z, Farahangiz M, Naderi N.   +4 more
europepmc   +1 more source

How to Optimize Healthy Volunteer Screening and Enrolment in Clinical Trials: A Qualitative and Quantitative Approach to Evaluate Processes and Healthy Volunteers' Perceptions

Clinical Pharmacology &Therapeutics, EarlyView.
Healthy volunteers (HVs) are essential for phase I trials, yet their recruitment and screening remain resource‐intensive and ethically complex. High screening failure (SF) rates highlight the need to evaluate and understand all aspects of the enrolment processes. We analyzed SF patterns in a large German HV cohort and explored participants' motivations,
Evelyn Krohmer, Manuela König, Cathrin J. Vogt, Marina Streckebein, Sybille Baumann, Max Blumenstock, Ruwen Böhm, Fabian Müller, Nadja Struß, Viktoria S. Wurmbach, Antje Blank   +10 more
wiley   +1 more source

Phase I Evaluation of Siltartoxatug, a First‐in‐Class Anti‐Tetanus Monoclonal Antibody: Safety, Pharmacokinetics and Pharmacodynamics in Healthy Australian and Chinese Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Xinyu Liu, Zhigang Liu, Xiaohu Kuang, Yueming Wang, Xiaoyi Liu, Jiyuan Ding, Xia Zhou, Xin Zhou, Qianyu Liang, Meizhuo Zhang, Hao Zhao, Qingqing Tan, Weihong Zheng, Huaxin Liao, Charlotte Lemech, Wanmei Wang   +15 more
wiley   +1 more source

What rural residents want from blood donation services: a discrete choice experiment. [PDF]

Front Public Health
Bello LA, Otekunrin OA, Ewemooje OS, Osuolale KA, Ezemelue PNA.   +4 more
europepmc   +1 more source

Knowledge, attitude, and practice on blood donation among undergraduate first-year engineering students in Nepal. [PDF]

PLoS One
Teli B, Rijal D, Gc S, Khanal A, Singh AK.   +4 more
europepmc   +1 more source

Potential Health Consequences of Regular Blood Donation: Current Evidence and Remaining Uncertainties. [PDF]

J Clin Med
Berli S, Kaiser MS, Schindler E, Tsakiris DA.   +3 more
europepmc   +1 more source