Results 251 to 260 of about 2,942,603 (300)

Prevalence and pattern of transfusion transmitted infections among blood donors visiting a tertiary care hospital, Pakistan. [PDF]

BMC Infect Dis
Iqbal K, Farhad S, Khan MSA, Jan MH, Khan IZ, Umair M, Hassan B, Hotak R.   +7 more
europepmc   +1 more source

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Standardization of the Monocyte Monolayer Assay: Lessons Learned From Laboratory Optimization and Literature Review. [PDF]

J Clin Lab Anal
Shastry S, Babu K, Chenna D, Mohan G, Iyer K.   +4 more
europepmc   +1 more source

How to Optimize Healthy Volunteer Screening and Enrolment in Clinical Trials: A Qualitative and Quantitative Approach to Evaluate Processes and Healthy Volunteers' Perceptions

Clinical Pharmacology &Therapeutics, EarlyView.
Healthy volunteers (HVs) are essential for phase I trials, yet their recruitment and screening remain resource‐intensive and ethically complex. High screening failure (SF) rates highlight the need to evaluate and understand all aspects of the enrolment processes. We analyzed SF patterns in a large German HV cohort and explored participants' motivations,
Evelyn Krohmer, Manuela König, Cathrin J. Vogt, Marina Streckebein, Sybille Baumann, Max Blumenstock, Ruwen Böhm, Fabian Müller, Nadja Struß, Viktoria S. Wurmbach, Antje Blank   +10 more
wiley   +1 more source

Knowledge, Attitudes, Motivations, and Practices of Blood Donation Among the Population of Saudi Arabia. [PDF]

Healthcare (Basel)
Altilasi SI, Hamze D, Elsarrag M, Sajid MR, Aldosari S.   +4 more
europepmc   +1 more source

Phase I Evaluation of Siltartoxatug, a First‐in‐Class Anti‐Tetanus Monoclonal Antibody: Safety, Pharmacokinetics and Pharmacodynamics in Healthy Australian and Chinese Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Xinyu Liu, Zhigang Liu, Xiaohu Kuang, Yueming Wang, Xiaoyi Liu, Jiyuan Ding, Xia Zhou, Xin Zhou, Qianyu Liang, Meizhuo Zhang, Hao Zhao, Qingqing Tan, Weihong Zheng, Huaxin Liao, Charlotte Lemech, Wanmei Wang   +15 more
wiley   +1 more source

Reentry of voluntary blood donors in Chongqing, China (2022-2024): a retrospective single-center analysis. [PDF]

Front Med (Lausanne)
Qin W, Hu T, Gan Y, Tian Y, Zhu X.
europepmc   +1 more source

Ethical issues in donation-based prosocial interventions for health: a scoping review. [PDF]

BMC Med Ethics
Hlatshwako TG, Santre D, Day S, Ho D, Tang W, Sugarman J, Tucker JD.   +6 more
europepmc   +1 more source

Anaesthetics considerations for organ retrieval in the voluntary assisted dying patient - case report. [PDF]

BMC Anesthesiol
Levin AB, Joshi Y, Vaidhya N, Kantianis J, Macdonald PS.   +4 more
europepmc   +1 more source

Caregivers' and healthcare providers' perceptions of blood availability, safety, and acceptability for patients with cancer in southwestern Uganda. [PDF]

PLOS Glob Public Health
Taremwa IM, Niyonzima N, Ashaba S, Akatukwasa C, Kemigisha E, Tusubira D, Ayebazibwe C, Atuhaire S, Choi MY, van Marle G, Heather HA, Natukunda B.   +11 more
europepmc   +1 more source