Results 41 to 50 of about 3,395 (297)
Unsteady behaviours of a volute in turbocharger turbine under pulsating conditions
Journal of the Global Power and Propulsion Society, 2017 Turbochargers are currently in their prime utilization period, which pushes for performance enhancement from conventional turbochargers and more often than not revisiting its design methodology.
Mingyang Yang +5 more
doaj +1 more source
Design and optimization of bionic Nautilus volute for a hydrodynamic retarder
Engineering Applications of Computational Fluid Mechanics, 2023 To reduce the energy loss of volute and improve the emergency braking performance of hydrodynamic retarder under design condition, a bionic volute optimization design method is proposed based on the Nautilus shell.
Wei Wei +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
, 2008 RESEARCH BACKGROUND Triply-Periodic Minimal Surfaces are mathematical objects that form a continuous partitioning of three-dimensional space with a curving surface of zero gaussian curvature.
Paul Minifie (18029191) +3 more
core +1 more source
MODERNIZATION OF THE FLOW SECTION OF THE MAIN CIRCULATION PUMP GCN 22600-87
Известия высших учебных заведений: Проблемы энергетики, 2018 In the presented work, a new version of the design of the flow-through part of the main circulation pump for NPPs with increased energy indices is proposed.
E. A. Ivanov +2 more
doaj +1 more source