Results 191 to 200 of about 887,639 (384)

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Epidemic Nausea and Vomiting [PDF]

, 1936
Reginald Miller, Maria C. Raven
openalex   +1 more source

Disposition and Absolute Bioavailability of Oral Imlunestrant in Healthy Women: A Phase 1, Open‐Label Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Imlunestrant (LY3484356) is a next‐generation orally bioavailable selective estrogen receptor degrader being investigated for the treatment of estrogen receptor–positive advanced breast and endometrial cancers. This Phase 1, open‐label, 2‐part study evaluated the disposition and absolute bioavailability of [14C]‐imlunestrant in 16 US‐based ...
Amita Datta‐Mannan, Boris Czeskis, Elaine Shanks, Eunice Yuen, Stephen Hall, Vivian Rodriguez Cruz, Kenneth Cassidy   +6 more
wiley   +1 more source

CONCERNING NAUSEA AND VOMITING DURING SPINAL ANESTHESIA [PDF]

, 1959
JULIE S. CROCKER, LEROY D. VANDAM
openalex   +1 more source

A Pharmacometric Method for Quantitative Determination of Improvement in Body Composition and Characterization of the Exposure–Response Relationship during Treatment of Obesity with Tirzepatide

Clinical Pharmacology &Therapeutics, EarlyView.
About half of the world's population is living with overweight or obesity. Tirzepatide is an approved treatment for chronic weight management. We sought to characterize the exposure–response relationship for weight reduction in patients with overweight or obesity and quantify the associated changes in body composition.
Emmanuel Chigutsa, Lucy Her, Xiaosu Ma, Shweta Urva, Karen Schneck   +4 more
wiley   +1 more source

Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial

Drug Design, Development and Therapy, 2016
Shoaleh Shami,1 Karim Nasseri,2 Mousa Shirmohammadi,3 Farzad Sarshivi,3 Negin Ghadami,3 Ebrahim Ghaderi,4 Mokhtar Pouladi,5 Arvin Barzanji1 1Department of Surgical Nursing, School of Nursing and Midwifery, Kurdistan University of Medical Sciences ...
Shami S, Nasseri K, Shirmohammadi M, Sarshivi F, Ghadami N, Ghaderi E, Pouladi M, Barzanji A   +7 more
doaj  

Aureomycin Treatment of Infantile Diarrhoea and Vomiting [PDF]

, 1950
J. HENNING MAGNUSSON, G Laurell, ERIK FRISELL, BlRGlTTA WERNER   +3 more
openalex   +1 more source

Hypertrophic pyloric stenosis [PDF]

, 2013
A 6-week old baby was brought to A&E by her parents, after a 3 week history of frequent vomiting, not tolerating feeds, and weight loss. She was well for the first 3 weeks of life, before she stopped tolerating any feeds. Despite several changes with the
Tabone, Trevor, Vella Baldacchino, Andrea   +1 more
core  

Semaglutide impairs bioavailability of alectinib: a note of warning based on a cross‐over pharmacokinetic drug‐drug interaction study

Cancer Communications, EarlyView.
Niels Heersche, Daan A. C. Lanser, Esther Oomen‐de Hoop, Attila Içli, Peter de Bruijn, Marthe S. Paats, Elisabeth F. C. van Rossum, Stijn L. W. Koolen, Ron H. N. van Schaik, Anne‐Marie C. Dingemans, G. D. Marijn Veerman, Ron H. J. Mathijssen   +11 more
wiley   +1 more source

Beyond Simple Grinding: Methylammonium Chloride Promotes Sustainable, Cylinder‐Free Mechanochemical Synthesis of Deferiprone

ChemSusChem, Accepted Article.
Thalassemias are a group of inherited haemoglobinopathies that disrupt normal haemoglobin synthesis. Managing these conditions often involves regular blood transfusions and iron chelation therapy to mitigate iron overload. Among the available chelators, deferoxamine, deferasirox, and deferiprone, the latter stands out notably for its use when other ...
Francesco Basoccu, Sara Piermarini, Tommaso Angelini, Massimiliano Mari, Edoardo Mariani, Alessandro Falchi, Andrea Porcheddu   +6 more
wiley   +1 more source