Results 121 to 130 of about 146,739 (334)

Exposure–Response Relationship between VWF/FVIII Activity and Spontaneous Bleeding Events Following Recombinant VWF Prophylaxis in Severe VWD

TH Open
Background Recombinant von Willebrand factor (rVWF, vonicog alfa, Takeda Pharmaceuticals USA) is indicated in adults diagnosed with von Willebrand disease (VWD).
Frank W.G. Leebeek, Giancarlo Castaman, Jean François Marier, Gülden Özen, Indranil Bhattacharya, Jingmei Zhang, Scarlett Wang, Yi Wang   +7 more
doaj   +1 more source

Burden of Haemophilia A in South Korea: A Serial Cross‐Sectional Study From 2008 to 2021

Haemophilia, EarlyView.
Abstract Background Overall use of factor VIII (FVIII) and prophylactic use have increased in South Korea over the past decade. However, there are no nationwide outcome data demonstrating its impact. This study aimed to identify patients with haemophilia A (PwHA) and observe trends in joint‐related outcomes and life‐threatening haemorrhages using ...
Sun‐Hong Kwon, Ji Kyoung Park, Hee Jo Baek, Jin Hyun Nam, Serim Min, Ae‐Ryeo Cho, Aeran Jung, Young‐Shil Park   +7 more
wiley   +1 more source

Humate-P for treatment of von Willebrand disease [letter] [PDF]

, 1988
EE Czapek, JJ Jr Gadarowski, J. Lara Ontiveros, JL Pedraza   +3 more
openalex   +1 more source

Current Practice Regarding Bleeding Disorders of Unknown Cause in the Netherlands: A National Survey

Haemophilia, EarlyView.
ABSTRACT Introduction About 40%–70% of persons with a clinically relevant bleeding tendency who are referred to haemostasis experts are classified as having a ‘bleeding disorder of unknown cause’ (BDUC) as no biological entity can be found after extensive laboratory testing.
Caroline M. A. Mussert, Amaury L. L. Monard, Tirsa T. van Duijl, Yvonne M. C. Henskens, Maartje van den Biggelaar, Roger E. G. Schutgens, Saskia E. M. Schols, Karin J. Fijnvandraat, Karina Meijer, Paul L. den Exter, Laurens Nieuwenhuizen, Iris van Moort, Marieke J. H. A. Kruip, Marjon H. Cnossen, Floor C. J. I. Heubel‐Moenen, for the BDUC‐iN study group   +15 more
wiley   +1 more source

The effect of DDAVP on plasma levels of von Willebrand antigen II in normal individuals and patients with von Willebrand's disease [PDF]

, 1984
DR McCarroll, ZM Ruggeri, RR Montgomery
openalex   +1 more source

Switching From Standard to Extended Half‐Life Coagulation Factor Replacement in Haemophilia: Clinical Outcomes and Costs of Care in Finland

Haemophilia, EarlyView.
ABSTRACT Introduction Real‐world data are needed to evaluate treatment implementation, outcomes and costs of care in haemophilia patients switching prophylaxis from standard half‐life (SHL) to extended half‐life (EHL) clotting factor concentrates (CFCs).
Mirkka Koivusalo, Timea Szanto, Tuomas Kovalainen, Aino Vesikansa, Outi Laine, Anu Partanen, Timo Siitonen, Marko Vesanen, Juha Mehtälä, Nina Sarnesto, Johanna Haapkylä, Anna‐Elina Lehtinen, Riitta Lassila   +12 more
wiley   +1 more source

Von Willebrand Disease in the elderly: clinical perspectives

Clinical Interventions in Aging, 2018
John Chapin Department of Hematology, Shire, Lexington, MA, USA Abstract: Von Willebrand disease (VWD) is an inherited bleeding disorder that affects up to 1% of the population. In most cases, VWD results from a mutation in the von Willebrand Factor (VWF)
Chapin J
doaj  

Ddavp-Induced Alterations In The Multimeric Composition Of Factor Viii/Von Willebrand Factor In Normal And Von Willebrand’S Disease Plasma [PDF]

, 1981
Zaverio M. Ruggeri, R Lombardi, P.M. Mannucci, T S Zimmerman   +3 more
openalex   +1 more source

Integrating Next‐Generation Sequencing Into Routine Molecular Diagnosis of Inherited Coagulation Factor Deficiencies: Real‐World Data From Spanish Patients

Haemophilia, EarlyView.
ABSTRACT Introduction Inherited coagulation factor deficiencies (ICFD) result from plasma protein deficiencies, impacting blood coagulation cascade and leading to haemorrhagic diathesis. Advancements in next‐generation sequencing (NGS) technology have enabled high‐throughput methods for molecular ICFD diagnosis.
Nina Borràs, Natàlia Comes, Lorena Ramírez, Rafael Parra, Carmen Altisent, Álvaro Lorenzo‐Vizcaya, Cristina Marzo‐Alonso, Maria‐Fernanda López‐Fernández, Mariana Canaro, María Falcón‐Rodríguez, Ángela Cortes‐Vidal, Mario A. Rios de Paz, José Antonio Rodríguez‐García, Ana Moreto‐Quintana, Perla Bandini, Carlos Hobeich, Irene Corrales, Francisco Vidal   +17 more
wiley   +1 more source

Data on the purification and crystallization of the loss-of-function von Willebrand disease variant (p.Gly1324Ser) of the von Willebrand factor A1 domain

Data in Brief, 2016
von Willebrand factor׳s (VWF) primary hemostatic responsibility is to deposit platelets at sites of vascular injury to prevent bleeding. This function is mediated by the interaction between the VWF A1 domain and the constitutively active platelet ...
James C. Campbell, Alexander Tischer, Venkata Machha, Laurie Moon-Tasson, Banumathi Sankaran, Choel Kim, Matthew Auton   +6 more
doaj