Results 141 to 150 of about 78,503 (229)
IKAROS Associated Immunodeficiency and Thrombotic Thrombocytopenic Purpura
ABSTRACT Pathogenic variants in IKZF1 (IKAROS) are linked to immunodeficiency, malignancy, and immune dysregulation. We describe a family with a rare IKZF1 variant presenting with humoral immunodeficiency and thrombotic thrombocytopenic purpura (TTP). A non‐consanguineous family was clinically monitored; clinical, immunological, and genetic data (exome
Ilia Spivak +7 more
wiley +1 more source
Rewriting the script: gene therapy and genome editing for von Willebrand Disease. [PDF]
Barraclough A +8 more
europepmc +1 more source
Abstract A 5‐year‐old male neutered standard poodle, presented with recurrent gingival margin haemorrhage and associated prolongations in prothrombin time and activated partial thromboplastin time, with repeatable demonstration of clinical (bleeding) and laboratory (prothrombin time, activated partial thromboplastin time) resolution with, and relapse ...
Jenny Reeve, Aiden Pang
wiley +1 more source
Impact of tranexamic acid on postpartum hemorrhage in type 1 von Willebrand disease treated with recombinant VWF. [PDF]
Machin NC +9 more
europepmc +1 more source
The Immunogenicity of Human Senescent Cells Is Dependent on the Senescence Inducer and Cell Type
Using multiple cell types and autologous immune cells, the authors present the first comprehensive evaluation of the immunogenicity of human senescent cells. Their findings demonstrate that, despite exhibiting a unique immunopeptidome, senescent fibroblasts are not recognized by immune cells.
Marie‐Lyn Goyer +11 more
wiley +1 more source
Bridging the Evidence Gap in von Willebrand Disease: A Call to Action for Equitable, Evidence-Based Care. [PDF]
Uminski K +3 more
europepmc +1 more source
ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando +7 more
wiley +1 more source
Avascular Necrosis and Minimal Trauma Fractures in Telomere Biology Disorders
Avascular Necrosis (AVN) and Minimal Trauma Fractures (MTF) cause significant morbidity in people with Telomere Biology Disorders (TBDs). They occur more frequently in young patients and in those with autosomal recessive (AR) or X‐linked recessive (XLR) than in autosomal dominant (AD) genotypes.
Arman M. Niknafs +3 more
wiley +1 more source
Oral post-surgical complications in patients with hemophilia and von Willebrand disease. [PDF]
Sousa LCP +3 more
europepmc +1 more source
ABSTRACT Relapsed/refractory (R/R) mantle cell lymphoma (MCL) remains a therapeutic challenge, particularly in patients with high‐risk features or prior exposure to Bruton's tyrosine kinase inhibitors (BTKis). The advent of T‐cell–redirecting immunotherapies, including chimeric antigen receptor T‐cell (CAR‐T) therapy and bispecific antibodies (BsAbs ...
Santino Caserta +10 more
wiley +1 more source

