Results 141 to 150 of about 78,503 (229)

IKAROS Associated Immunodeficiency and Thrombotic Thrombocytopenic Purpura

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Pathogenic variants in IKZF1 (IKAROS) are linked to immunodeficiency, malignancy, and immune dysregulation. We describe a family with a rare IKZF1 variant presenting with humoral immunodeficiency and thrombotic thrombocytopenic purpura (TTP). A non‐consanguineous family was clinically monitored; clinical, immunological, and genetic data (exome
Ilia Spivak, Daniella Magen, Karin Weiss, Tamar Paperna, Suhair Hanna, Amos Etzioni, Adi Miller‐Barmak, Yonatan Butbul Aviel   +7 more
wiley   +1 more source

Rewriting the script: gene therapy and genome editing for von Willebrand Disease. [PDF]

Front Genome Ed
Barraclough A, Bär I, van Duijl T, Fijnvandraat K, Eikenboom JCJ, Leebeek FWG, Bierings R, Voorberg J, Trasanidou D.   +8 more
europepmc   +1 more source

Recurrent haemorrhage, due to vitamin K‐dependent coagulopathy, as the primary presenting complaint in a dog with naturally occurring hypoadrenocorticism

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 5‐year‐old male neutered standard poodle, presented with recurrent gingival margin haemorrhage and associated prolongations in prothrombin time and activated partial thromboplastin time, with repeatable demonstration of clinical (bleeding) and laboratory (prothrombin time, activated partial thromboplastin time) resolution with, and relapse ...
Jenny Reeve, Aiden Pang
wiley   +1 more source

Impact of tranexamic acid on postpartum hemorrhage in type 1 von Willebrand disease treated with recombinant VWF. [PDF]

Blood Adv
Machin NC, Brooks MM, Vehec D, Ivanco D, Lawryk B, Seaman CD, Xavier F, Shiva S, Verdoni A, Ragni MV.   +9 more
europepmc   +1 more source

The Immunogenicity of Human Senescent Cells Is Dependent on the Senescence Inducer and Cell Type

Aging Cell, Volume 25, Issue 2, February 2026.
Using multiple cell types and autologous immune cells, the authors present the first comprehensive evaluation of the immunogenicity of human senescent cells. Their findings demonstrate that, despite exhibiting a unique immunopeptidome, senescent fibroblasts are not recognized by immune cells.
Marie‐Lyn Goyer, Anthony Sonn, Basma Benabdallah, Oanh Le, Joshua Dulong, Joana Oschwald, Isabelle Sirois, Anca Apavaloaei, Leslie Hesnard, Jean V. Guimond, Elie Haddad, Christian Beauséjour   +11 more
wiley   +1 more source

Bridging the Evidence Gap in von Willebrand Disease: A Call to Action for Equitable, Evidence-Based Care. [PDF]

Haemophilia
Uminski K, James P, Connell N, Khalife R.   +3 more
europepmc   +1 more source

The Calcium‐Binding Protein S100A10 (p11) Is Required for Normal Motor Performance by Regulating Vesicle Dynamics at Excitatory Synapses

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando, Guillermo Rodríguez‐Bey, Rosendo G. Hernández, Ángela Gento‐Caro, Ángel M. Pastor, Antonio Campos‐Caro, David González‐Forero, Bernardo Moreno‐López   +7 more
wiley   +1 more source

Avascular Necrosis and Minimal Trauma Fractures in Telomere Biology Disorders

Clinical Genetics, Volume 109, Issue 2, Page 286-293, February 2026.
Avascular Necrosis (AVN) and Minimal Trauma Fractures (MTF) cause significant morbidity in people with Telomere Biology Disorders (TBDs). They occur more frequently in young patients and in those with autosomal recessive (AR) or X‐linked recessive (XLR) than in autosomal dominant (AD) genotypes.
Arman M. Niknafs, Neelam Giri, Marena R. Niewisch, Sharon A. Savage   +3 more
wiley   +1 more source

Oral post-surgical complications in patients with hemophilia and von Willebrand disease. [PDF]

Hematol Transfus Cell Ther
Sousa LCP, Félix ECGDC, Hespanhol W, Pinheiro RDS.   +3 more
europepmc   +1 more source

T‐Cell–Redirecting Immunotherapies in Relapsed/Refractory Mantle Cell Lymphoma: Current Evidence, Sequencing, and Future Directions

European Journal of Haematology, Volume 116, Issue 2, Page 129-141, February 2026.
ABSTRACT Relapsed/refractory (R/R) mantle cell lymphoma (MCL) remains a therapeutic challenge, particularly in patients with high‐risk features or prior exposure to Bruton's tyrosine kinase inhibitors (BTKis). The advent of T‐cell–redirecting immunotherapies, including chimeric antigen receptor T‐cell (CAR‐T) therapy and bispecific antibodies (BsAbs ...
Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Massimo Gentile   +10 more
wiley   +1 more source