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von Willebrand factor and von Willebrand disease.
[Rinsho ketsueki] The Japanese journal of clinical hematology, 2016von Willebrand factor (VWF) has two major roles in hemostasis, as a form of molecular glue which functions in platelet plug formation and as a protective transporter for coagulation factor VIII (FVIII). VWF shows a multimeric chain structure composed of 270 kDa subunits containing binding domains for FVIII, platelet and collagens. Biosynthesis, storage,
T. Matsui, J. Hamako
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Maternal-Fetal Evidence Based Guidelines, 2022
Objective: To determine the clinical features and laboratory parameters of patients of von Willebrand disease (vWD) in our population. Study Design: Cross-sectional study.
Melody Safarzadeh
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Objective: To determine the clinical features and laboratory parameters of patients of von Willebrand disease (vWD) in our population. Study Design: Cross-sectional study.
Melody Safarzadeh
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New England Journal of Medicine, 2016
Von Willebrand's disease is the most common inherited bleeding disorder and is generally transmitted as an autosomal dominant trait. It is mainly associated with mucosal bleeding and excessive bleeding after trauma or surgery. A variety of effective treatments are available.
Leebeek, F.W.G., Eikenboom, J.C.J.
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Von Willebrand's disease is the most common inherited bleeding disorder and is generally transmitted as an autosomal dominant trait. It is mainly associated with mucosal bleeding and excessive bleeding after trauma or surgery. A variety of effective treatments are available.
Leebeek, F.W.G., Eikenboom, J.C.J.
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Pediatric Clinics of North America, 2008
von Willebrand disease is a common inherited bleeding disorder and many cases are diagnosed in childhood. It has a negative impact on the quality of life of affected individuals; therefore, it is important that the condition be recognized and diagnosed.
Jeremy Robertson +2 more
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von Willebrand disease is a common inherited bleeding disorder and many cases are diagnosed in childhood. It has a negative impact on the quality of life of affected individuals; therefore, it is important that the condition be recognized and diagnosed.
Jeremy Robertson +2 more
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Human Pathology, 1987
von Willebrand disease (vWD) is a bleeding disorder characterized by a complex hemostatic defect. Abnormal platelet function, usually reflected by a prolonged bleeding time, is the result of a quantitative or qualitative defect of von Willebrand factor (vWF).
Theodore S. Zimmerman +1 more
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von Willebrand disease (vWD) is a bleeding disorder characterized by a complex hemostatic defect. Abnormal platelet function, usually reflected by a prolonged bleeding time, is the result of a quantitative or qualitative defect of von Willebrand factor (vWF).
Theodore S. Zimmerman +1 more
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von Willebrand disease and von Willebrand factor
Haemophilia, 2022AbstractSummaryProgress in both basic and translational research into the molecular mechanisms of VWD can be seen in multiple fields.Genetics of VWDIn the past several decades, knowledge of the underlying pathogenesis of von Willebrand disease (VWD) has increased tremendously, thanks in no small part to detailed genetic mapping of the von Willebrand ...
Brooke, Sadler +2 more
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Patterns of von Willebrand Disease Screening in Girls and Adolescents With Heavy Menstrual Bleeding.
Obstetrics and Gynecology, 2018OBJECTIVE To estimate the frequency of von Willebrand disease screening and factors that affect screening frequency in a national sample of girls and adolescents with heavy menstrual bleeding.
Amanda E. Jacobson +4 more
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Pediatric Blood & Cancer, 2012
AbstractLong‐term prophylaxis is not as well known in Von Willebrand disease (VWD) as in hemophilia but attempts to evaluate prophylaxis scientifically in VWD have started. A few cohort studies have been reported. In an international effort the Von Willebrand disease prophylaxis network (VWD PN) has been formed to investigate the role of prophylaxis in
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AbstractLong‐term prophylaxis is not as well known in Von Willebrand disease (VWD) as in hemophilia but attempts to evaluate prophylaxis scientifically in VWD have started. A few cohort studies have been reported. In an international effort the Von Willebrand disease prophylaxis network (VWD PN) has been formed to investigate the role of prophylaxis in
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Annual Review of Medicine, 1997
▪ Abstract von Willebrand's disease (vWD) arises from abnormalities in von Willebrand factor (vWF), an adhesive glycoprotein uniquely involved in key aspects of both primary and secondary hemostasis. The current classification distinguishes disorders arising from partial (type 1) or complete (type 3) deficiencies and from qualitative defects (type 2).
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▪ Abstract von Willebrand's disease (vWD) arises from abnormalities in von Willebrand factor (vWF), an adhesive glycoprotein uniquely involved in key aspects of both primary and secondary hemostasis. The current classification distinguishes disorders arising from partial (type 1) or complete (type 3) deficiencies and from qualitative defects (type 2).
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