Results 91 to 100 of about 110,723 (302)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A process evaluation of the City of Cape Town Business Support Voucher Programme
, 2007 Includes bibliographical references (leaves 74-78).This dissertation focuses on a process evaluation of the City of Cape Town (CoCT) Business Support Voucher Programme (BSVP) which assessed whether this programme was implemented as intended.
Wright, Carol
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Empowering Domestic Workers: A Critical Analysis of the Belgian Service Voucher System
Societies, 2017 Domestic cleaners lack bargaining power, which can prevent them from being in control of their work quality. The ‘service voucher system’ is expected to change the power position of domestics.
Sarah Mousaid +2 more
doaj +1 more source
, 2023 Over the past two decades, the humanitarian sector has witnessed a significant expansion in the use of cash and voucher assistance to persons affected by disasters.
Harpring, Russell
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Jurnal Informatika, 2017 Perusahaan Listrik Negara (PLN) has implemented a smart electricity system or prepaid electricity. The customers pay the electricity voucher first before use the electricity.
Ricky Akbar, Husnil Kamil
doaj +1 more source
BENCHMARKING EVALUATION OF SME SUPPORT PROGRAM:CASE OF CONSULTING SUBSIDIARY GRANTS IN SLOVENIA AND FYROM [PDF]
SMEs need external business support, in particular during the early development stage. Government agencies have developed a number of initiatives and voucher system is targeted at counselling combined with information and training.
Jaka Vadnjal
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source