Results 81 to 90 of about 34,477 (304)

What are the resourcing requirements for an Aboriginal and Torres Strait Islander primary health care research project?

Public Health Research & Practice, 2020
Objective and importance: To explore the role of resourcing during an Aboriginal and Torres Strait Islander primary health care research project. Study type: Process evaluation using grounded theory approaches of a national Aboriginal and Torres ...
Sara Farnbach, Graham Gee, Anne-Marie Eades, John Robert Evans , Jamie Fernando, Belinda Hammond, Matty Simms, Karrina DeMasi, Nick Glozier , Maree L Hackett   +9 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

School Vouchers in Practice: Competition Won't Hurt You! [PDF]

An important issue in the debate on voucher systems and school choice is what effects competition from independent schools will have on public schools. Sweden has made a radical reform of its system for financing schools.
Bergström, Fredrik, Sandström, F. Mikael   +1 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

School vouchers and student achievement: recent evidence, remaining questions [PDF]

In this article, we review the empirical evidence on the impact of education vouchers on student achievement, and briefly discuss the evidence from other forms of school choice.
Lisa Barrow, Cecilia Elena Rouse
core  

Associations between a cash voucher intervention, food consumption, and coping strategies in Somali food-insecure populations

Agriculture & Food Security
Background This cross-sectional study aimed to explore the association between cash voucher assistance on building community resiliency and improving food security among 1371 households (HH) living in northern and southern regions of Somalia.
Theresa Fang, Andy Tran, Beryl Oranga, Ryan Kopper, Yunhee Kang   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Tourism in pandemic: the role of digital travel vouchers in China

Humanities & Social Sciences Communications
The COVID-19 pandemic has created significant challenges to the global economy, especially within the tourism industry. Economic downturns and psychological barriers make it even more challenging to attract tourists back.
Yingtong Chen, Fei Wu, Dayong Zhang, Qiang Ji   +3 more
doaj   +1 more source

WIC fruit and vegetable vouchers: Small farms face barriers in supplying produce

California Agriculture, 2015
By October 2009, all 50 states had implemented a revised WIC program with produce vouchers for millions of eligible families. USDA economists had projected the vouchers would raise net farm revenues by $76 million. In response to such a
Shermain Hardesty, Penny Leff, Aziz Retired - Baameur, Jose Aguiar, Manuel Jimenez, Yelena Zeltser, Lucia Kaiser   +6 more
doaj   +1 more source