Results 101 to 110 of about 22,955 (198)

Cell‐based polygenic risk scores predict clinical progression and prioritize network‐based therapeutic targets in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract BACKGROUND Late‐onset Alzheimer's disease (AD) exhibits substantial biological heterogeneity. We developed a framework linking cell‐type–specific polygenic risk profiles to precision medicine in AD. METHODS Cell‐based polygenic risk scores (cbPRSs) derived from single‐nucleus RNA‐seq co‐expression networks were evaluated in Alzheimer's Disease
Nathan Sahelijo, Priya Rajagopalan, Lu Qian, Rufuto Rahman, Daniel Goldstein, Sophia I. Thomopoulos, David A. Bennett, Lindsay A. Farrer, Thor D. Stein, Li Shen, Heng Huang, Kwangsik Nho, Andrew J. Saykin, Christos Davatzikos, Paul M. Thompson, Julia TCW, Gyungah R. Jun   +16 more
wiley   +1 more source

MRI evidence of gray matter loss in COVID‐19 patients with cognitive and olfactory disorders

Annals of Clinical and Translational Neurology
Objective The aim of this study was to assess COVID‐19‐related gray matter (GM) structural alterations in two distinct groups of patients presenting with the prevailing and distinctive COVID‐19‐related neurological symptoms – isolated olfactory disorders
Serena Capelli, Alberto Arrigoni, Angela Napolitano, Giulio Pezzetti, Andrea Remuzzi, Rosalia Zangari, Ferdinando Luca Lorini, Maria Sessa, Anna Caroli, Simonetta Gerevini   +9 more
doaj   +1 more source

Disrupted Sensory–Motor Network Integrity in Excessive Online Gaming: Insight From Multimodal Morphometric Mapping

Brain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Introduction Excessive online gaming (EOG) is a transitional stage between recreational gaming and internet gaming disorder (IGD), characterized by impaired self‐control and escalating engagement. Early identification of neural and behavioral vulnerabilities is crucial for understanding IGD development. Methods Fifty‐nine young adults (30 EOG,
Zulalanmu Abudouxukuer, Michael Afiadenyo, Zhenzhen Yang, Benjamin Becker, Stefania Ferraro, Elijah Agoalikum, Seth Kwadjo Angmorterh, Francis Tanam Djankpa, Latif Adams, Bharat B. Biswal, Benjamin Klugah‐Brown   +10 more
wiley   +1 more source

Growth of White Matter Signal Aberrations and Cortical Changes in Men and Women: A 9‐Year Multiple‐Time‐Point Longitudinal MRI Study in Older Adults

Human Brain Mapping, Volume 47, Issue 14, October 1, 2026.
Greater growth of white matter signal aberration (WMSA) volume, the most common age‐related finding on brain MRI, is connected to increased cortical thinning, more so in men than women. In men only, the cortical regions experiencing increased thinning due to WMSA growth displayed a concomitant cortical area expansion.
Asta K. Håberg, Line S. Reitlo, Torgil R. Vangberg   +2 more
wiley   +1 more source

Orbitofrontal and Medial Frontal Gray Matter Volumes Are Associated With Hyperactivity Traits in 2548 Nonclinical Adults

Human Brain Mapping, Volume 47, Issue 14, October 1, 2026.
In 2548 nonclinical adults, smaller orbitofrontal and medial frontal cortex gray matter volumes were associated with higher hyperactivity traits (r = −0.07 to −0.08). These small, robust effects, consistent with ENIGMA ADHD findings, suggest frontal structure–trait mapping extends to the nonclinical ADHD continuum.
Handityo Aulia Putra, Kaechang Park
wiley   +1 more source

Lobular and Voxel‐Wise Genetic Influences on Cerebellar Gray Matter Volume and Associations With Social and Trait Anxiety in Twins

Human Brain Mapping, Volume 47, Issue 14, October 1, 2026.
Our twin MRI study revealed spatially heterogeneous and scale‐dependent genetic influences on the cerebellum, higher in cognitive‐related than motor‐related regions, while voxel‐wise mapping revealed variation within regions. Despite substantial genetic influence of social and trait anxiety, their genetic associations with cerebellar volumes remain ...
Tugce Yildiz‐Ahola, Granit Kastrati, Peter Fransson, Fredrik Åhs, Tomas Furmark, Amirhossein Manzouri, Dagmar Timmann, Kristoffer N. T. Månsson, Jörgen Rosén   +8 more
wiley   +1 more source

Prospective Head Motion Correction in T1‐ and T2‐Weighted Long Echo Train Sequences Using Servo Navigation

Magnetic Resonance in Medicine, Volume 96, Issue 4, Page 1741-1754, October 2026.
ABSTRACT Purpose To integrate MR‐based servo navigation in MPRAGE and 3D‐TSE sequences and demonstrate its potential for prospective head motion correction in structural imaging. Methods Repeated modules of servo navigators were inserted before each preparation pulse of MPRAGE and 3D‐TSE sequences (before‐prep) for rapid convergence of motion parameter
Matthias Serger, Malte Riedel, Rüdiger Stirnberg, Thomas Ulrich, Nicolas Boulant, Klaas P. Pruessmann, Tony Stöcker, Philipp Ehses   +7 more
wiley   +1 more source

Neural Correlates of Apathy in Multiple System Atrophy: A Clinical and Perfusion Imaging Study

European Journal of Neurology, Volume 33, Issue 10, October 2026.
In 76 patients with multiple system atrophy (MSA) and relatively preserved global cognition, apathy was present in 55.3%, with no association with motor severity or depressive symptoms. Reduced medial prefrontal cortex (mPFC) perfusion was independently associated with apathy after adjustment for clinical variables, while exploratory covariance ...
Yuki Nakagawa, Atsuhiko Sugiyama, Yoshikazu Nakano, Hajime Yokota, Shigeki Hirano, Masahiro Namiki, Tatsuya Yamamoto, Yoshitaka Yamanaka, Shoichi Ito, Masahiro Mori   +9 more
wiley   +1 more source

Longitudinal MRI studies of children with attention‐deficit/hyperactivity disorder: A systematic review

Psychiatry and Clinical Neurosciences, Volume 80, Issue 10, Page 789-812, October 2026.
We reviewed longitudinal magnetic resonance imaging (MRI) studies exploring the brain development of children with attention‐deficit/hyperactivity disorder (ADHD). Specifically, we conducted a systematic review of papers published until 9 September 2025 in English on pediatric patients with ADHD.
Ayaka Ishii‐Takahashi, Yuzu Yoshimaru, Dwi Muhammad, Takuya Kawahara, Rio Yamaguchi   +4 more
wiley   +1 more source

ABSTRACTS

Precision Radiation Oncology, EarlyView.
wiley   +1 more source