Results 51 to 60 of about 775,117 (329)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Spare parts optimization for maintenance of electronic module constructed devices

open access: yesVojnotehnički Glasnik, 1996
The paper presents spare parts model supply for one type of electronic module constructed devices, in a multilevel maintenance system. The procedure of spare parts optimization for maintenance of such devices is explained and an example of spare parts ...
Dušan Korolija
doaj   +1 more source

Informatics Education 2020 [PDF]

open access: yes, 2019
PIT-UN writes about Good Systems and the Conference on Undergraduate Informatics Education on March 3-4, 2020.Office of the VP for ...
Technology University Network, The Public Interest
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Evaluation of maintainability of special purpose vehicles

open access: yesVojnotehnički Glasnik, 1999
In this work, based on data which are taken from real service for the engine of a particular vehicle, evaluation of the maintainability was carried out using the distribution method of long - lasing time of the procedure of maintenance like the ...
Ljubiša Brkić
doaj   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte   +13 more
wiley   +1 more source

Sistemi za globalno pozicioniranje - vojne primene

open access: yesVojnotehnički Glasnik, 1999
Od 1971. godine sistem za globalno pozicioniranje, postao je nezaobilazno sredstvo u domenu pozicioniranja i navigacije. Međutim, malo ko je očekivao da će tako brzo, za manje od 10 godina, pretrpeti toliku minijaturizaciju, usavršavanje i kombinovanje ...
Miroslav Savanović
doaj   +1 more source

Efficient shoot regeneration of medicinal plant Haplophyllum tuberculatum by direct and indirect organogenesis and genetic fidelity assessment using Inter Simple Sequence Repeats markers

open access: yesFrontiers in Plant Science, 2022
In vitro plant cell and tissue cultures are potent tools to propagating germplasm resources in conserving and managing plant genetic resources. A reliable micropropagation protocol was developed for efficient callus proliferation and direct and indirect ...
Mohammed Alsafran   +4 more
doaj   +1 more source

Parametrization of PMNS matrix based on dodeca-symmetry

open access: yes, 2011
The dodeca symmetry is designed to obtain the Cabibbo angle $\theta_C^{\rm CKM}$ approximately $15^{\rm o}$ and the (11) element of $\Vp$ as $\cos 30^{\rm o}$, leading to $\theta_1^{\rm PMNS}+\theta_C^{\rm CKM}\simeq 45^{\rm o}$.
Kim, Jihn E., Seo, Min-Seok
core   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons   +31 more
wiley   +1 more source

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