Results 1 to 10 of about 1,596 (93)

VPAC1 and VPAC2 Receptor Heterozygosity Confers Distinct Biological Properties to BV2 Microglial Cells [PDF]

Cells
Microglial cells, the resident immune cells of the central nervous system (CNS), are essential for maintaining CNS homeostasis. Dysregulation of microglial function is implicated in the pathogenesis of various neurodegenerative diseases.
Xin Ying Rachel Song, Margo Iris Jansen, Rubina Marzagalli, Giuseppe Musumeci, Velia D’Agata, Alessandro Castorina   +5 more
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Bordetella spp. utilize the type 3 secretion system to manipulate the VIP/VPAC2 signaling and promote colonization and persistence of the three classical Bordetella in the lower respiratory tract [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionBordetella are respiratory pathogens comprised of three classical Bordetella species: B. pertussis, B. parapertussis, and B. bronchiseptica. With recent surges in Bordetella spp.
Nicholas J. First, Jose Pedreira-Lopez, Manuel R. F. San-Silvestre, Katelyn M. Parrish, Xiao-Hong Lu, Monica C. Gestal   +5 more
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Prokineticin 2 neurons form diverse subpopulations in the suprachiasmatic nucleus and rely on VPAC2-signaling for diurnal rhythmicity [PDF]

Frontiers in Physiology
IntroductionProkineticin 2 (PK2) is believed to function as an output molecule, relaying circadian rhythms of behavior and physiology from the suprachiasmatic nucleus (SCN).
Ida Stangerup, Ida Stangerup, Birgitte Georg, Jens Hannibal, Jens Hannibal   +4 more
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Increased pituitary adenylate cyclase-activating peptide genes expression in the prefrontal cortex in schizophrenia in relation to suicide [PDF]

Frontiers in Molecular Neuroscience, 2023
IntroductionPituitary adenylate cyclase-activating peptide (PACAP) is a stress-related neuropeptide that is produced in several brain areas. It acts by 3 receptors: PACAP type-1 (PAC1), vasoactive intestinal peptide (VIP) -1 and -2 (VPAC1 and 2). Data on
Zala Slabe, Zala Slabe, Rawien A. Balesar, Ronald W. H. Verwer, Gorazd Drevenšek, Dick F. Swaab, Dick F. Swaab   +6 more
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VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model [PDF]

The Journal of Headache and Pain
Background Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target.
Song Guo, Rikke Holm Rasmussen, Anders Hay-Schmidt, Messoud Ashina, Ayodeji A. Asuni, Jeppe Møller Jensen, Anja Holm, Sabrina Prehn Lauritzen, Glenn Dorsam, Jens Hannibal, Birgitte Georg, David Møbjerg Kristensen, Jes Olesen, Sarah Louise Christensen   +13 more
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Vasoactive intestinal peptide excites GnRH neurons via KCa3.1, a potential player in the slow afterhyperpolarization current [PDF]

Frontiers in Cellular Neuroscience
Vasoactive intestinal peptide (VIP) is an important component of the suprachiasmatic nucleus (SCN) which relays circadian information to neuronal populations, including GnRH neurons.
Stephanie Constantin, Clarisse Quignon, Katherine Pizano, David M. Shostak, Susan Wray   +4 more
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Pituitary adenylyl cyclase-activating polypeptide modulates the stress response: the involvement of different brain areas and microglia [PDF]

Frontiers in Psychiatry
Stress is necessary for survival. However, chronic unnecessary stress exposure leads to cardiovascular, gastrointestinal and neuropsychiatric disorders. Thus, understanding the mechanisms involved in the initiation and maintenance of the stress response ...
Anika Singh, Paul Shim, Sadaf Naeem, Shafiqur Rahman, Kabirullah Lutfy   +4 more
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Therapeutic potential of vasoactive intestinal peptide and its receptor VPAC2 in type 2 diabetes

Frontiers in Endocrinology, 2022
Owing to the increasing prevalence of type 2 diabetes, the development of novel hypoglycemic drugs has become a research hotspot, with the ultimate goal of developing therapeutic drugs that stimulate glucose-induced insulin secretion without inducing ...
Xintong Hou, Xintong Hou, Dan Yang, Dan Yang, Guimei Yang, Guimei Yang, Mengnan Li, Mengnan Li, Jian Zhang, Jian Zhang, Jiaxin Zhang, Jiaxin Zhang, Yi Zhang, Yunfeng Liu   +13 more
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PAC1- and VPAC2 receptors in light regulated behavior and physiology: Studies in single and double mutant mice. [PDF]

PLoS ONE, 2017
The two sister peptides, pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) and their receptors, the PAC1 -and the VPAC2 receptors, are involved in regulation of the circadian timing system.
Jens Hannibal, Birgitte Georg, Jan Fahrenkrug   +2 more
doaj   +1 more source

The Circadian Clock Is Sustained in the Thyroid Gland of VIP Receptor 2 Deficient Mice

Frontiers in Endocrinology, 2021
VIP/VPAC2-receptor signaling is crucial for functioning of the circadian clock in the suprachiasmatic nucleus (SCN) since the lack results in disrupted synchrony between SCN cells and altered locomotor activity, body temperature, hormone secretion and ...
Birgitte Georg, Jan Fahrenkrug, Henrik L. Jørgensen, Henrik L. Jørgensen, Jens Hannibal, Jens Hannibal   +5 more
doaj   +1 more source