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Brain circadian clocks timing the 24h rhythms of behavior. [PDF]
NPJ Biol Timing SleepMendoza J.
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Role of VPAC2 receptor in monocrotaline-induced pulmonary hypertension in rats
Journal of Applied Physiology, 2014Pulmonary hypertension (PH) is associated with significant morbidity and mortality. Vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase activating peptide (PACAP) have pulmonary vasodilatory and positive inotropic effects via receptors VPAC1 and VPAC2, which possess a similar affinity for both peptides, and PAC1, a PACAP-preferring ...
Motokazu, Koga +4 more
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2021
The evidence is mounting for a role for abnormal signaling of the stress peptide pituitary adenylate cyclase activating polypeptide (PACAP) and its canonical receptor PAC1 in the pathogenesis of sudden infant death syndrome. In this study, we investigated whether the PACAP receptors PAC1 or VPAC2 are involved in the neonatal cardiorespiratory response
Karlene T. Barrett +3 more
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The evidence is mounting for a role for abnormal signaling of the stress peptide pituitary adenylate cyclase activating polypeptide (PACAP) and its canonical receptor PAC1 in the pathogenesis of sudden infant death syndrome. In this study, we investigated whether the PACAP receptors PAC1 or VPAC2 are involved in the neonatal cardiorespiratory response
Karlene T. Barrett +3 more
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Quantifizierung von VPAC2-Rezeptor-Protein in Mastzellen normaler Haut
Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie, 2011Mastzellen spielen an den Grenzflachen des Organismus eine wesentliche Rolle bei der Reaktion auf Umwelteinflusse. Diese Umwelteinflusse werden durch Neuropeptide und ihre Rezeptoren vermittelt. Ein Kandidatenrezeptor fur die regulatorische Steuerung des Gefastonus bei entzundlichen Hauterkrankungen ist der VPAC2-Rezeptor des Vasoaktiven Intestinalen ...
Tanja C. Fischer +5 more
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Hexanoylation of a VPAC2 receptor-preferring ligand markedly increased its selectivity and potency
Peptides, 2004We synthesized a VIP analog that combines mutations that decrease the affinity for the VPAC1 receptor but maintain a high affinity for the VPAC2 receptor with an amino-terminal hexanoylation that increases the affinity for the VPAC2 receptor with a limited decrease in the affinity of the VPAC1 receptor.
Langer, Ingrid +5 more
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VPAC2 receptor mediates VIP-potentiated insulin secretion via ion channels in rat pancreatic β cells
Experimental Cell Research, 2023Vasoactive intestinal peptide (VIP), a small neuropeptide composing of 28 amino acids, functions as a neuromodulator with insulinotropic effect on pancreatic β cells, in which it is of vital importance in regulating the levels of blood glucose. VIP potently agonizes VPAC2 receptor (VPAC2-R).
Xin Zhao +9 more
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