Results 11 to 20 of about 1,665 (152)

Genome-Wide Translatome Analysis Following Low-Dose Ketamine to Reveal Novel Targets for Antidepressant Treatment. [PDF]

Synapse
ABSTRACT Low‐dose ketamine is an efficacious antidepressant for treatment‐resistant unipolar and bipolar depressed patients. Major depressive disorder patients receiving a single infusion report elevated mood within 2 h, and ketamine's antidepressant effects have been observed as long as 7 days posttreatment.
Miller OH, Grabole N, Wells I, Bellier L, Nassi JJ, Hall BJ.   +5 more
europepmc   +2 more sources

VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer. [PDF]

Cancer Res
Abstract Pancreatic ductal adenocarcinoma (PDAC) harbors a complex tumor microenvironment, and cross-talk among cells in the tumor microenvironment can contribute to drug resistance and relapse. Vasoactive intestinal peptide (VIP) is overexpressed in PDAC, and VIP receptors expressed on T cells are a targetable pathway that sensitizes
Passang T, Wang S, Zhang H, Zeng F, Hsu PC, Wang W, Li JM, Liu Y, Ravindranathan S, Lesinski GB, Waller EK.   +10 more
europepmc   +3 more sources

Loss of neuropeptide signalling alters temporal expression of mouse suprachiasmatic neuronal state and excitability. [PDF]

Eur J Neurosci
Abstract Individual neurons of the hypothalamic suprachiasmatic nuclei (SCN) contain an intracellular molecular clock that drives these neurons to exhibit day‐night variation in excitability. The neuropeptide vasoactive intestinal polypeptide (VIP) and its cognate receptor, VPAC2, are synthesized by SCN neurons and this intercellular VIP‐VPAC2 receptor
Wegner S, Belle MDC, Chang PS, Hughes ATL, Conibear AE, Muir C, Samuels RE, Piggins HD.   +7 more
europepmc   +2 more sources

Development and pharmacological characterization of novel multi- calcitonin gene-related peptide and pituitary adenylate cyclase-activating peptide receptor antagonists. [PDF]

Headache
Abstract Objective This study aimed to provide proof‐of‐concept that multi‐receptor antagonist peptides can be generated by covalently linking independent antagonist peptides that block calcitonin gene‐related peptide (CGRP8‐37) or pituitary adenylate cyclase‐activating peptide (PACAP)/vasoactive intestinal peptide (VIP) (PACAP6‐38) activity ...
Tasma Z, Siow A, Harris PWR, Brimble MA, Hay DL, Walker CS.   +5 more
europepmc   +2 more sources

Role for VPAC2 Receptor-Mediated Signals in Pancreas Development [PDF]

Diabetes, 2003
Mature pancreatic cells develop from progenitors that proliferate and differentiate into endocrine and exocrine cells. This development is thought to be controlled by secreted soluble factors acting on their target cells after binding to membrane receptors. Here, we analyzed the impact on embryonic pancreatic development of ligands that bind to protein
Latif, Rachdi, Jean-Claude, Marie, Raphael, Scharfmann   +2 more
openaire   +2 more sources

Cardiac fibrosis induced by high-fat diet in ApoE-deficient male mice is exacerbated by genetic deletion of PACAP-PAC1 signaling. [PDF]

J Neuroendocrinol
Abstract Cardiac fibrosis is characterized by an excessive accumulation of extracellular matrix proteins and occurs in a variety of cardiac diseases, such as the highly prevalent syndrome heart failure with preserved ejection fraction (HFpEF) and other cardiac disorders.
Schubart JM, Schaefer MKH, Bonaterra GA, Mey L, Schwarzbach H, Pankuweit S, Ausbuettel F, Eiden LE, Weyand S, Weihe E, Kinscherf R, Waechter C.   +11 more
europepmc   +2 more sources

Role of VPAC1 and VPAC2 receptors in the etiology of pregnancy rhinitis: an experimental study in rats

Brazilian Journal of Otorhinolaryngology, 2022
Introduction: Pregnancy rhinitis is a common sex hormone-related otorhinolaryngological disorder. There are some epidemiological and physiological studies on pregnancy rhinitis, but histopathological and biomolecular changes have not been studied ...
Burak Ulkumen, Muhammet Burak Batir, Burcu Artunc Ulkumen, Halil Gursoy Pala, Seda Vatansever, Sirri Cam   +5 more
doaj   +1 more source

Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular Models

Frontiers in Neuroscience, 2021
Pituitary adenylate cyclase-activating polypeptide (PACAP, gene name ADCYAP1) is a multifunctional neuropeptide involved in brain development and synaptic plasticity.
Yukio Ago, Satoshi Asano, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, James A. Waschek   +6 more
doaj   +1 more source

Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism

Frontiers in Neuroscience, 2020
Clinical studies have shown that microduplications at 7q36.3, containing VIPR2, confer significant risk for schizophrenia and autism spectrum disorder (ASD).
Shuto Takeuchi, Takuya Kawanai, Ryosuke Yamauchi, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Satoshi Asano, Atsuko Hayata-Takano, Atsuko Hayata-Takano, Takanobu Nakazawa, Takanobu Nakazawa, Koji Yano, Naotaka Horiguchi, Shinsaku Nakagawa, Shinsaku Nakagawa, Shinsaku Nakagawa, Kazuhiro Takuma, Kazuhiro Takuma, James A. Waschek, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Yukio Ago, Yukio Ago, Yukio Ago, Yukio Ago   +27 more
doaj   +1 more source

Modified BuShenYiQi formula alleviates experimental allergic asthma in mice by negative regulation of type 2 innate lymphoid cells and CD4+ type 9 helper T cells and the VIP–VPAC2 signalling pathway

Pharmaceutical Biology, 2021
Context Modified BuShenYiQi formula (M-BYF) is derived from BuShenYiQi formula, used for the treatment of allergic asthma. The exact effect and mechanism of M-BYF on the improvement of asthma remain unclear.
Muhua Huang, Jinfeng Wu, Jingcheng Dong
doaj   +1 more source