Results 21 to 30 of about 1,665 (152)

Seasonal changes in the expression of PACAP, VPAC1, VPAC2, PAC1 and testicular activity in the testis of the muskrat (Ondatra zibethicus)

European Journal of Histochemistry, 2022
Pituitary adenylate cyclase-activating polypeptide (PACAP) plays an important role in the steroidogenesis and spermatogenesis in the testis through its receptors PAC1, VPAC1, and VPAC2.
Zeqi Tang, Xiaojie Yuan, Yuming Bai, Yiming Guo, Haolin Zhang, Yingying Han, Zhengrong Yuan, Qiang Weng   +7 more
doaj   +1 more source

Distribution of the VPAC2 Receptor in Peripheral Tissues of the Mouse [PDF]

Endocrinology, 2004
Abstract The neuropeptide vasoactive intestinal peptide (VIP) exerts its actions through two structurally related G protein-coupled receptors (VPAC1 and VPAC2). Pituitary adenylate cyclase-activating polypeptide (PACAP) is also a potent agonist of VPAC1 and VPAC2 receptors as well as of a third, PACAP-specific receptor (PAC1).
Anthony J, Harmar, W John, Sheward, Christine F, Morrison, Beatrice, Waser, Mathias, Gugger, Jean Claude, Reubi   +5 more
openaire   +2 more sources

Drug Repositioning For Allosteric Modulation of VIP and PACAP Receptors

Frontiers in Endocrinology, 2021
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two neuropeptides that contribute to the regulation of intestinal motility and secretion, exocrine and endocrine secretions, and homeostasis of the ...
Ingrid Langer, Dorota Latek
doaj   +1 more source

A model for the fast synchronous oscillations of firing rate in rat suprachiasmatic nucleus neurons cultured in a multielectrode array dish. [PDF]

PLoS ONE, 2014
When dispersed and cultured in a multielectrode dish (MED), suprachiasmatic nucleus (SCN) neurons express fast oscillations of firing rate (FOFR; fast relative to the circadian cycle), with burst duration ∼10 min, and interburst interval varying from 20 ...
Andrey R Stepanyuk, Pavel V Belan, Nikolai I Kononenko   +2 more
doaj   +1 more source

Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells. [PDF]

Biofactors
Vasoactive intestinal peptide (VIP) acts as a promoter of human osteogenesis, enhancing the expression of early osteoblast markers and favoring both bone matrix formation and proper cytoskeletal reorganization. Moreover, VIP could be exerting a direct modulatory role on the osteoblast to osteoclast signaling by downregulating the receptor activator of ...
Castro-Vázquez D, Arribas-Castaño P, García-López I, Gutiérrez-Cañas I, Pérez-García S, Lamana A, Villanueva-Romero R, Cabrera-Martín A, Tecza K, Martínez C, Juarranz Y, Gomariz RP, Carrión M.   +12 more
europepmc   +2 more sources

Vasoactive intestinal peptide and its receptors in human ovarian cortical follicles. [PDF]

PLoS ONE, 2012
BACKGROUND: Ovarian cryopreservation is one option for fertility preservation in patients with cancer. The danger of reseeding malignancies could be eliminated by in vitro maturation of primordial follicles from the frozen-thawed tissue.
Rinat Gabbay-Benziv, Asangla Ao, Benjamin Fisch, Li Zhang, Galia Oron, Gania Kessler-Icekson, Avi Ben-Haroush, Haim Krissi, Ronit Abir   +8 more
doaj   +1 more source

Molecular Basis of Class B GPCR Selectivity for the Neuropeptides PACAP and VIP

Frontiers in Molecular Biosciences, 2021
The related neuropeptides PACAP and VIP, and their shared PAC1, VPAC1 and VPAC2 receptors, regulate a large array of physiological activities in the central and peripheral nervous systems.
Chenyi Liao, Chenyi Liao, Jacob M. Remington, Victor May, Jianing Li   +4 more
doaj   +1 more source

PACAP key interactions with PAC1, VPAC1, and VPAC2 identified by molecular dynamics simulations

Journal of Biomolecular Structure and Dynamics, 2023
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) belongs to the glucagon/secretin family. PACAP interacts with the pituitary adenylate cyclase-activating polypeptide receptor type 1 (PAC1) and vasoactive intestinal peptide receptors 1 and 2 (VPAC1 and VPAC2), exhibiting functions in the immune, endocrine, and nervous systems.
Fernando Augusto T. P. Meireles, Deborah Antunes, Jairo R. Temerozo, Dumith Chequer Bou-Habib, Ernesto Raul Caffarena   +4 more
openaire   +2 more sources

Clinical Relevance of VPAC1 Receptor Expression in Early Arthritis: Association with IL-6 and Disease Activity. [PDF]

PLoS ONE, 2016
The vasoactive intestinal peptide (VIP) receptors VPAC1 and VPAC2 mediate anti-inflammatory and immunoregulatory responses in rheumatoid arthritis (RA).
Iria V Seoane, Ana M Ortiz, Lorena Piris, Amalia Lamana, Yasmina Juarranz, Rosario García-Vicuña, Isidoro González-Álvaro, Rosa P Gomariz, Carmen Martínez   +8 more
doaj   +1 more source

Alterations in Gut Microbiota and Upregulations of VPAC2 and Intestinal Tight Junctions Correlate with Anti-Inflammatory Effects of Electroacupuncture in Colitis Mice with Sleep Fragmentation

Biology, 2022
The relationship between inflammatory bowel disease and sleep disturbances is complicated and of increasing interest. We investigated the inflammatory and immunological consequences of EA in sleep-deprived colitis and found that dextran sulfate sodium ...
Geng-Hao Liu, Xin-Cheng Zhuo, Yueh-Hsiang Huang, Hsuan-Miao Liu, Ren-Chin Wu, Chia-Jung Kuo, Ning-Hung Chen, Li-Pang Chuang, Shih-Wei Lin, Yen-Lung Chen, Huang-Yu Yang, Tzung-Yan Lee   +11 more
doaj   +1 more source