Results 31 to 40 of about 1,665 (152)

A novel recombinant, VPAC2-selective agonist enhancing insulin release and glucose disposal [PDF]

Acta Pharmacologica Sinica, 2007
To obtain the recombinant, VPAC2-selective ( VPAC2: type 3 receptor of pituitary adenylate cyclase activating polypeptide which shared by vasoactive intestinal peptide) agonist with effects on glucose disposal by intein-mediated, single column purification.A gene encoding 32-amino acid peptide named rMBAY was designed and synthesized and cloned into ...
Rong-jie, Yu, Ngai-lik, Tam, Yuan, Gao, Zhi-hong, Zeng, Tian-hong, Zhou, An, Hong   +5 more
openaire   +2 more sources

Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia

Biology Open, 2013
Summary Primary cilia protrude from the cell surface of many cell types in the human body and function as cellular antennae via ciliary membrane localized receptors.
Livana Soetedjo, De'Vona A. Glover, Hua Jin   +2 more
doaj   +1 more source

Pathophysiological implication of the VPAC2 receptor in psychiatric disorders

Folia Pharmacologica Japonica, 2018
The advent of the genomic era has led to the discovery of linkages of several genes and pathways to schizophrenia and autism spectrum disorder (ASD) that may serve as new biomarkers or therapeutic targets for these diseases. Two large-scale genetic studies published early in 2011 provided evidence that functional microduplications at 7q36.3, containing
Yukio, Ago, Atsuko, Hayata, Hitoshi, Hashimoto   +2 more
openaire   +3 more sources

Macrophage Resistance to HIV-1 Infection Is Enhanced by the Neuropeptides VIP and PACAP. [PDF]

PLoS ONE, 2013
It is well established that host factors can modulate HIV-1 replication in macrophages, critical cells in the pathogenesis of HIV-1 infection due to their ability to continuously produce virus.
Jairo R Temerozo, Rafael Joaquim, Eduardo G Regis, Wilson Savino, Dumith Chequer Bou-Habib   +4 more
doaj   +1 more source

Localization of the neuropeptides pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal peptide, and their receptors in the basal brain blood vessels and trigeminal ganglion of the mouse CNS; an immunohistochemical study

Frontiers in Neuroanatomy, 2022
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are structurally related neuropeptides that are widely expressed in vertebrate tissues. The two neuropeptides are pleiotropic and have been associated with
Anne Marie Lund, Anne Marie Lund, Jens Hannibal, Jens Hannibal   +3 more
doaj   +1 more source

Effect of inactivating mutations on phosphorylation and internalization of the human VPAC2 receptor [PDF]

Journal of Molecular Endocrinology, 2005
The VPAC2 receptor, as all members of the G-protein-coupled receptor (GPCR)-B family, has two highly conserved motifs in the third intracellular (IC3) loop: a lysine and a leucine located at the amino-terminus and two basic residues separated by a leucine and an alanine at the carboxyl-terminus.
Langer, Ingrid, Langlet, Christelle, Robberecht, Patrick   +2 more
openaire   +2 more sources

Rhinologic Conditions of Pregnancy: A Retrospective Cohort Study. [PDF]

OTO Open
Abstract Objective To better understand the prevalence, risk factors, and management strategies of pregnancy‐related rhinologic conditions. Study Design Retrospective cohort study from January 2013 to January 2023. Setting Tertiary level Otolaryngology–Head and Neck Surgery clinic. Methods Pregnant patients with rhinologic concerns were included.
Eltawil Y, Callander JK, Loftus PA.
europepmc   +2 more sources

Signal Transduction by VIP and PACAP Receptors

Biomedicines, 2022
Homeostasis of the human immune system is regulated by many cellular components, including two neuropeptides, VIP and PACAP, primary stimuli for three class B G protein-coupled receptors, VPAC1, VPAC2, and PAC1.
Ingrid Langer, Jérôme Jeandriens, Alain Couvineau, Swapnil Sanmukh, Dorota Latek   +4 more
doaj   +1 more source

Impaired neonatal cardiorespiratory responses to hypoxia in mice lacking PAC1 or VPAC2 receptors [PDF]

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2019
The stress peptide pituitary adenylate cyclase activating polypeptide (PACAP) and its specific receptor PACAP type 1 receptor (PAC1) have been implicated in sudden infant death syndrome (SIDS). PACAP is also critical to the neonatal cardiorespiratory response to homeostatic stressors identified in SIDS, including hypoxia.
Karlene T. Barrett, Shabih U. Hasan, Morris H. Scantlebury, Richard J. A. Wilson   +3 more
openaire   +2 more sources

VPAC Receptor Subtypes Tune Purinergic Neuron-to-Glia Communication in the Murine Submucosal Plexus

Frontiers in Cellular Neuroscience, 2017
The enteric nervous system (ENS) situated within the gastrointestinal tract comprises an intricate network of neurons and glia which together regulate intestinal function. The exact neuro-glial circuitry and the signaling molecules involved are yet to be
Pieter Vanden Berghe, Candice Fung, Candice Fung, Werend Boesmans, Carla Cirillo, Jaime P. P. Foong, Joel C. Bornstein   +6 more
doaj   +1 more source