Results 41 to 50 of about 1,665 (152)
The PACAP/PAC1 Receptor System and Feeding
Brain Sciences, 2021 Pituitary adenylyl cyclase activating polypeptide (PACAP) belongs to the vasoactive intestinal polypeptide (VIP)/secretin/glucagon superfamily. PACAP is present in two forms (PACAP-38 and PACAP-27) and binds to three guanine-regulatory (G) protein ...
Keerthana Sureshkumar +3 more
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HIV-1 integration is inhibited by stimulation of the VPAC2 neuroendocrine receptor
Virology, 2007 Successful HIV-1 infection requires a number of specific stages leading to integration of the provirus. We previously suggested that members of the VPAC neuroendocrine receptor family may play a role in HIV-1 infection. We now show that stimulation of the VPAC2 receptor with specific agonists provides strong resistance to HIV-1 infection.
Bokaei, Payman Baradar +3 more
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Gastro Hep Advances, 2022 Background and Aims: Vasoactive intestinal peptide (VIP) is a neuropeptide involved in the regulation of feeding behavior and circadian rhythms, metabolism, and immunity.
Aaron C. Ericsson +6 more
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Synthesis and In Vitro Characterization of Glycopeptide Drug Candidates Related to PACAP1–23
Molecules, 2021 The search for efficacious treatment of neurodegenerative and progressive neuroinflammatory diseases continues, as current therapies are unable to halt or reverse disease progression.
Christopher R. Apostol +6 more
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Effect of VPAC2 agonist on improving cardiac output in pulmonary hypertension
The FASEB Journal, 2013 Pulmonary hypertension (PH) is associated with significant perioperative risk for major complications, including cardiac arrest and death. Vasoactive intestinal peptide (VIP) and its related peptide PACAP are known to have vasodilatory and protective effects in several organs and VIP has been expected to be promising treatment option for PH.
Yusuke Mizuno +4 more
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VPAC2 receptor expression in human normal and neoplastic tissues: evaluation of the novel MAB SP235 [PDF]
Endocrine Connections, 2015 The vasoactive intestinal peptide receptor 2 (VPAC2) is widely distributed throughout the body and is also overexpressed in a variety of human neoplastic tissues. However, little is known about its precise tissue distribution, regulation and function, which is in part be due to the lack of specific monoclonal anti-VPAC2 antibodies.
Schulz, Stefan +4 more
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Discovery of PACAP and its receptors in the brain
The Journal of Headache and Pain, 2018 Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularly high homology (~ 68%) to VIP.
Takahiro Hirabayashi +2 more
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Nature Communications, 2020 Circadian activity modulation in the suprachiasmatic nucleus (SCN) is a network-level emergent property that requires neuropeptide VIP signaling, yet the precise cellular mechanisms are unknown. Patton et al.
Andrew P. Patton +7 more
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Frontiers in Cellular Neuroscience, 2020 Vasoactive intestinal peptide (VIP) is an important modulatory peptide throughout the CNS acting as a neurotransmitter, neurotrophic or neuroprotective factor.
Diana Cunha-Reis +3 more
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Biology, 2022 Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylate-Cyclase-Activating Peptide (PACAP) are anti-inflammatory neuropeptides that play important roles in human and rodent gut microbiota homeostasis and host immunity.
Emma Hawley +5 more
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