Results 51 to 60 of about 1,665 (152)
Frontiers in Pharmacology, 2021 Worldwide, more than 20 million people suffer from schizophrenia, but effective and definitive new therapeutic drugs/treatments have not been established.
Kotaro Sakamoto +16 more
doaj +1 more source
The cell-autonomous clock of VIP receptor VPAC2 cells drives circadian behaviour [PDF]
, 2020 AbstractCircadian (∼daily) rhythms pervade mammalian behaviour. They are generated by cell-autonomous, transcriptional/translational feedback loops (TTFL), active in all tissues. This distributed clock network is co-ordinated by the principal circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN).
Ryan Hamnett +3 more
openaire +1 more source
Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis
Journal of Neurochemistry, Volume 170, Issue 1, January 2026.Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal +3 more
wiley +1 more source
Pituitary adenylate cyclase activating peptide (PACAP) participates in adipogenesis by activating ERK signaling pathway. [PDF]
PLoS ONE, 2013 Pituitary adenylate cyclase activating peptide (PACAP) belongs to the secretin/glucagon/vasoactive intestinal peptide (VIP) family. Its action can be mediated by three different receptor subtypes: PAC1, which has exclusive affinity for PACAP, and VPAC1 ...
Tatjana Arsenijevic +6 more
doaj +1 more source
Evidence for the involvement of VPAC1 and VPAC2 receptors in pressure‐induced vasodilatation in rodents [PDF]
The Journal of Physiology, 2004 A transient increase in skin blood flow in response to an innocuous local pressure application, defined as pressure‐induced vasodilatation (PIV), delays the occurrence of ischaemia, suggesting a protective feature against applied pressure. The PIV response depends on capsaicin‐sensitive nerve fibres and calcitonin gene‐related peptide (CGRP) has been ...
Lionel, Fizanne +3 more
openaire +2 more sources
Frontiers in Neuroanatomy, 2020 Prolactin (PRL) is a versatile hormone and serves a broad variety of physiological functions besides lactation. The release of PRL from lactotrophs in the pituitary has in rodents been shown to be released with a circadian pattern depending on the ...
Ida Stangerup, Jens Hannibal
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a member of the vasoactive intestinal polypeptide (VIP)-the secretin-glucagon family of neuropeptides. They act through two classes of receptors: PACAP type 1 (PAC1) and type 2 (VPAC1 and VPAC2)
Jérôme Ruel +8 more
doaj +1 more source
Periosteum Organoid: Biomimetic Design Inspired From the Bone Healing Process
Exploration, Volume 5, Issue 6, December 2025.Periosteum is a key factor in bone regeneration and repair, and the development of periosteum organoids with the help of organoid technology can achieve accelerated bone regeneration. This review explores the structure and function of the periosteum, the design and application of periosteum organoids, and their potential integration with bone organoids,
Shuyue Hao +7 more
wiley +1 more source
Modeling the VPAC2-Activated cAMP/PKA Signaling Pathway: From Receptor to Circadian Clock Gene Induction [PDF]
Biophysical Journal, 2006 Increasing evidence suggests an important role for VPAC2-activated signal transduction pathways in maintaining a synchronized biological clock in the suprachiasmatic nucleus (SCN). Activation of the VPAC2 signaling pathway induces per1 gene expression in the SCN and phase-shifts the circadian clock.
Hao, Haiping +4 more
openaire +2 more sources
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source