Results 61 to 70 of about 1,665 (152)
BioEssays, Volume 47, Issue 11, November 2025.Regarding pituitary gonadotropin regulation, recent studies have shown that in mammals, FSH and LH are regulated by a single GnRH (solo GnRH model), whereas in teleosts, they are regulated by CCK (FSH‐RH) and GnRH (LH‐RH), respectively (dual GnRH model).
Daichi Kayo +3 more
wiley +1 more source
Frontiers in Endocrinology, 2012 VIP plays diverse and important role in human physiology and physiopathology and their receptors constitute potential targets for the treatment of several diseases such as neurodegenerative disorder, asthma, diabetes and inflammatory diseases.
Ingrid eLanger
doaj +1 more source
Biomedicines, 2021 We aimed to evaluate the direct action of VIP on crucial molecules involved in human osteoclast differentiation and function. We also investigated the relationship between VIP serum levels and bone remodeling mediators in early arthritis patients.
David Castro-Vazquez +11 more
doaj +1 more source
Biology, 2022 Vasoactive Intestinal Peptide binds with high affinity to VPAC1R and VPAC2R, thus regulating key physiologic functions. Previously, we documented in VIP−/− mice a leaner body phenotype and altered metabolic hormones.
Daniel Sanford +7 more
doaj +1 more source
Advanced Healthcare Materials, Volume 14, Issue 24, September 18, 2025.The tissue and functional benefits are demonstrated with local, sustained delivery of an anti‐inflammatory peptide, pituitary adenylate cyclase‐activating polypeptide (PACAP), for stroke treatment in a mouse model. Prolonged PACAP treatment modulated astrocyte and microglia toward pro‐reparative phenotypes, enhanced neuroprotection and preservation of ...
Eric Ho +7 more
wiley +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, Volume 3, Issue 3, September 2025.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
Scientific Reports, 2023 Macrophages are a major population of immune cells in solid cancers, especially colorectal cancers. Tumor-associated macrophages (TAMs) are commonly divided into M1-like (tumor suppression) and M2-like (tumor promotion) phenotypes.
Wararat Kittikulsuth +8 more
doaj +1 more source
British Journal of Pharmacology, Volume 182, Issue 15, Page 3612-3627, August 2025.Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano +6 more
wiley +1 more source
Journal of Cellular Physiology, Volume 240, Issue 7, July 2025.Caveolin1 interacts with PTH1R at membrane‐bound microdomains delaying receptor internalization, promoting cAMP signaling over calcium and ERK1/2 kinase pathways, and regulating bone formation and bone remodeling gene expression upon agonist stimulation in osteoblastic cells.
Sara Heredero‐Jiménez +7 more
wiley +1 more source
Expression, identification and biological effects of a novel VPAC2-specific agonist with high stability and bioactivity [PDF]
Acta Biochimica et Biophysica Sinica, 2010 The development of rBAY, a recombinant peptide with the similar sequence of synthetic BAY55-9837, as a potential peptide therapeutic for type 2 diabetes is still a challenge mainly because of its poor stability in aqueous solution. To improve the peptide stability and bioactivity and investigate its biological effects for VPAC2-specific activation ...
Yi, Ma, Min, Ma, Yun, Dai, An, Hong
openaire +2 more sources