Results 141 to 150 of about 950,912 (267)

A typology for vulnerability and agriculture in Sub-Saharan Africa: [PDF]

"This paper considers vulnerability reduction in Sub-Saharan Africa (SSA) from a more aggregated macro viewpoint. We focus on risk related to agriculture, since vulnerability and agriculture are intimately linked in SSA due to the location of the poor ...
Chamberlin, Jordan, Zhang, Xiaobo, Rockmore, Marc   +2 more
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Vulnerability to welfare change during economic shocks: Evidence from the 1998 Russian crisis [PDF]

Using changes in consumption as a proxy for "vulnerability" we identify the characteristics associated with vulnerability around the time of the 1998 Russian financial crisis.
Carmen A. Li, Christopher J. Gerry
core  

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

On the Economic Vulnerability of Low-Income Countries [PDF]

This paper examines the relevance of the concept of economic vulnerability for low income countries, a topic of recent concern in several international bodies.
Patrick GUILLAUMONT
core   +2 more sources

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Vulnerability and public service delivery in China from 1985 to 1999 [PDF]

This research focused on the determinants of vulnerability, as measured by the variable of expenditure on food consumption, by the quality of public service delivery as measured by three education variables (amount of students per teacher in primary ...
Mary-Françoise RENARD, Richard SCHIERE
core  

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Vulnerability to Agricultural Drought in Western Orissa: A Case Study of Representative Blocks [PDF]

The nature of vulnerability to agricultural drought in three study blocks of Bolangir district in western Orissa has been analysed. The indexing and vulnerability profile method have been used for assessing the nature of drought vulnerability, coping ...
Swain, Mamata, Swain, Mrutyunjay
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source