Results 51 to 60 of about 345,903 (245)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Spatiotemporal Responses and Vulnerability of Vegetation to Drought in the Ili River Transboundary Basin: A Comprehensive Analysis Based on Copula Theory, SPEI, and NDVI

Remote Sensing
The Ili River Transboundary Basin is an important area within the Belt and Road Initiative, and its ecological security impacts China–Kazakhstan diplomatic relations and the building of the Belt and Road Initiative.
Yaqian Li, Jianhua Yang, Jianjun Wu, Zhenqing Zhang, Haobing Xia, Zhuoran Ma, Liang Gao   +6 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Microservice Vulnerability Analysis: A Literature Review With Empirical Insights

IEEE Access
Microservice architectures are revolutionizing both small businesses and large corporations, igniting a new era of innovation with their exceptional advantages in maintainability, reusability, and scalability.
Raveen Kanishka Jayalath, Hussain Ahmad, Diksha Goel, Muhammad Shuja Syed, Faheem Ullah   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A Hybrid Graph-Based Risk Assessment and Attack Path Detection Model for IoT Systems

IEEE Access
The rapid expansion of Internet of Things (IoT) technology has led to a proliferation of smart devices and interconnected systems. Critical factors such as production limitations, cost constraints, and insufficient technical capabilities have rendered ...
Ferhat Arat, Sedat Akleylek, Zaliha Yuce Tok   +2 more
doaj   +1 more source

Analysing the vulnerability of buildings to climate change: Summer heat and flooding

Meteorologische Zeitschrift, 2013
The REGKLAM project (Development and Testing of an Integrated Regional Climate Change Adaption Programme for the Model Region Dresden) forms part of the KLIMZUG programme (Managing Climate Change in the Regions for the Future) funded by the German ...
Johannes Nikolowski, Valeri Goldberg, Jakob Zimm, Thomas Naumann   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Study on Shaking Table Test and Vulnerability Analysis of 220 kV Indoor Substation in High-Intensity Areas

Infrastructures
This study investigates the seismic performance of the V3.0 220 kV standard-designed substation of the Southern Power Grid, located in a high-intensity seismic zone, with a focus on the application of seismic isolation technology.
Jie Feng, Liuhuo Wang, Yueqing Chen, Xiaohui Wu, Dayang Wang   +4 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source