Results 161 to 170 of about 32,051 (269)

Vulnerability in the context of EU asylum policies : the challenges of identification and prioritisation

, 2018
Vulnerability as a criterion for allocating rights and protection is an emerging concept in the current EU asylum legislation (Dir. 2003/9) and ECtHR case-law.
Caicedo, Natalia, Centre d'Estudis i Recerca en Migracions (CER-Migracions), Romano, Andrea   +2 more
core  

Appraisal of groundwater susceptibility to pollution using hybrid framework of stable isotopes and indexed approach. [PDF]

Sci Rep
Hagagg K, Sirag NM.
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

FIJICLIM description and users guide

, 2000
The FIJICLIM prototype is based on PACCLIM which was developed by the International Global Change Institute (IGCI) as part of the Pacific Islands Climate Change Assistance Programme (PICCAP) executed by the South Pacific Regional Environment Programme ...
Kenny, Gavin J., de Wet, Neil, Ye, Wei, Warrick, Richard A.   +3 more
core  

Criminal governance and extortion in informal economies: fear as a mechanism of territorial control in Lima. [PDF]

Front Sociol
Espinoza Escobar JH, Sotelo-Llancari S, La Rosa Salvador VI.   +2 more
europepmc   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

A Review of Climate Justice: Vulnerability and Protection, by Henry Shue

, 2015
Henry Shue\u27s Climate Justice: Vulnerability and Protection offers an extremely useful and readable guide to the key challenges, workable objectives, and possible responses to a major-if not the major-global problem faced today.
Rhodes, Edwardo
core   +1 more source

Editorial: Masculinities, empathy, care, and non-violence. [PDF]

Front Sociol
Moura T, Caruso H, Garraio J.
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Forensic-psychiatric and medico-legal challenges in euthanasia and assisted suicide for patients with mental disorders: balancing autonomy, vulnerability, and professional responsibility. [PDF]

Front Psychiatry
Tripi D, Giantesani M, Arena JF, Ferracuti S.   +3 more
europepmc   +1 more source