Results 101 to 110 of about 4,939,818 (296)

Building world narratives for climate change impact, adaptation and vulnerability analyses [PDF]

The impacts of climate change on human systems depend not only on the level of emissions but also on how inherently vulnerable these systems are to the changing climate.
Przyluski Valentin, Stéphane Hallegatte, Adrien Vogt-Schilb   +2 more
core  

Establishing a methodology to measure vulnerability of unhoused populations to climate change in the United States

Climate Risk Management
The interactions between climate change and homelessness in the United States are neither widely documented nor uniformly quantified. Individuals who experience homelessness are commonly not accounted for in community, state, or federal climate change ...
Harris R. Eisenhardt, Thomas Peterson, Michael Schwebel   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Malawi2020: Vulnerability and Risk Assessment in the tea industry

, 2016
In June 2016, Oxfam conducted a Vulnerability and Risk Assessment (VRA) exercise in Mulanje, Southern Malawi, in the context of the Malawi2020 Tea Revitalization Programme (Malawi2020).
Kachepa, Chimwemwe, Weinmann, Wolfgang, Thole, Edward, Edward Thole, Daniel Morchain, Helen Jeans, Lefu, Hyton, Jeans, Helen, Mtegha-Kawamba, Linda, Chimwemwe Kachepa, Linda Mtegha-Kawamba, Wolfgang Weinmann, Hyton Lefu, Morchain, Daniel   +13 more
core   +1 more source

Vulnerability Analysis against Natural and Technological Threats: A Comparative Assessment in Tehran Metropolis Gas Supply Network

International Journal of Occupational Hygiene, 2021
Introduction: Resilience as a counterpoint to vulnerability can reduce the vulnerability of various natural, man-made and technological threats in complex technical systems.
Esmaeil Shoja, Mohammad Hassan Cheraghali, Alireza Rezghi Rostami, Alireza Derakhshani   +3 more
doaj  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Mapping vulnerability to climate change [PDF]

This paper develops a methodology for regional disaggregated estimation and mapping of the areas that are ex-ante the most vulnerable to the impacts of climate change and variability and applies it to Tajikistan, a mountainous country highly vulnerable ...
Bonch-Osmolovskiy, Misha, Heltberg, Rasmus   +1 more
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source